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    Impaired information processing speed and attention allocation in multiple sclerosis patients versus controls: a high-density EEG study.

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    Authors
    Whelan, R
    Lonergan, R
    Kiiski, H
    Nolan, H
    Kinsella, K
    Hutchinson, M
    Tubridy, N
    Reilly, R B
    Affiliation
    Department of Neurology, St. Vincent's University Hospital, University College, Dublin, Dublin, Ireland. Robert.whelan@tcd.ie
    Issue Date
    2012-02-01T10:28:22Z
    MeSH
    Acoustic Stimulation/methods
    Adult
    Attention Deficit Disorder with Hyperactivity/*etiology
    Cognition Disorders/*etiology
    Electroencephalography/methods
    Event-Related Potentials, P300/physiology
    Female
    Humans
    Male
    Mental Processes/*physiology
    Middle Aged
    Multiple Sclerosis/*complications
    Neuropsychological Tests
    Numerical Analysis, Computer-Assisted
    Photic Stimulation/methods
    Reaction Time/*physiology
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    Citation
    J Neurol Sci. 2010 Jun 15;293(1-2):45-50.
    Journal
    Journal of the neurological sciences
    URI
    http://hdl.handle.net/10147/207019
    DOI
    10.1016/j.jns.2010.03.010
    PubMed ID
    20399448
    Abstract
    BACKGROUND: The no-go P3a is a variant of the P300 event-related potential (ERP) that indexes speed of information processing and attention allocation. The aim of this study was to compare ERP findings with results from the paced auditory serial addition test (PASAT) and to quantify latency, amplitude and topographical differences in P3a ERP components between multiple sclerosis (MS) patients and controls. PATIENTS AND METHODS: Seventy-four subjects (20 relapsing remitting (RRMS) patients, 20 secondary progressive (SPMS) patients and 34 controls) completed a three-stimulus oddball paradigm (target, standard, and non-target). Subjects participated in separate visual and auditory tasks while data were recorded from 134 EEG channels. Latency differences were tested using an ANCOVA. Topographical differences were tested using statistical parametric mapping. RESULTS: Visual P3a amplitude correlated with PASAT score in all MS patients over frontal and parietal areas. There were significant differences in latency, amplitude, and topography between MS patients and controls in the visual condition. RRMS and SPMS patients differed in visual P3a latency and amplitude at frontal and parietal scalp regions. In the auditory condition, there were latency differences between MS patients and controls only over the parietal region. CONCLUSION: The present results demonstrate that information processing speed and attention allocation are impaired in MS.
    Language
    eng
    ISSN
    1878-5883 (Electronic)
    0022-510X (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jns.2010.03.010
    Scopus Count
    Collections
    St. Vincent's University Hospital

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