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dc.contributor.authorFitzgerald, S F
dc.contributor.authorO'Gorman, J
dc.contributor.authorMorris-Downes, M M
dc.contributor.authorCrowley, R K
dc.contributor.authorDonlon, S
dc.contributor.authorBajwa, R
dc.contributor.authorSmyth, E G
dc.contributor.authorFitzpatrick, F
dc.contributor.authorConlon, P J
dc.contributor.authorHumphreys, H
dc.date.accessioned2012-02-01T09:57:25Z
dc.date.available2012-02-01T09:57:25Z
dc.date.issued2012-02-01T09:57:25Z
dc.identifier.citationJ Hosp Infect. 2011 Nov;79(3):218-21.en_GB
dc.identifier.issn1532-2939 (Electronic)en_GB
dc.identifier.issn0195-6701 (Linking)en_GB
dc.identifier.pmid21856042en_GB
dc.identifier.doi10.1016/j.jhin.2011.06.015en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207004
dc.description.abstractStaphylococcus aureus bloodstream infections (BSI) are a significant cause of morbidity and mortality in haemodialysis patients. This study describes a 12-year retrospective review of S. aureus BSI in a large haemodialysis centre in a tertiary referral hospital. The overall rate of S. aureus BSI was 17.9 per 100 patient-years (range 9.7-36.8). The rate of meticillin-resistant S. aureus (MRSA) BSI was 5.6 per 100 patient-years (range 0.9-13.8). Infective complications occurred in 11% of episodes, the most common being infective endocarditis (7.6%). Ten percent of patients died within 30 days of S. aureus being isolated from blood. Most cases of S. aureus BSI (83%) were related to vascular catheters. The provision of lower-risk vascular access, such as arteriovenous fistulae, and reduced use of intravascular catheters should be priorities in all haemodialysis units. Where alternative vascular access cannot be established, interventions to reduce the risk of catheter-related infections should be implemented to reduce morbidity and mortality in this vulnerable patient group.
dc.language.isoengen_GB
dc.subject.meshBacteremia/*epidemiology/microbiology/mortalityen_GB
dc.subject.meshCatheter-Related Infections/epidemiology/microbiology/mortalityen_GB
dc.subject.meshCross Infection/epidemiology/microbiology/mortalityen_GB
dc.subject.meshEndocarditis/epidemiology/microbiologyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIreland/epidemiologyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMethicillin-Resistant Staphylococcus aureus/*isolation & purificationen_GB
dc.subject.meshRenal Dialysis/*adverse effectsen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshStaphylococcal Infections/*epidemiology/microbiology/mortalityen_GB
dc.subject.meshStaphylococcus aureus/*isolation & purificationen_GB
dc.titleA 12-year review of Staphylococcus aureus bloodstream infections in haemodialysis patients: more work to be done.en_GB
dc.contributor.departmentDepartment of Microbiology, Beaumont Hospital, Dublin, Ireland., s.fitzgerald@svuh.ieen_GB
dc.identifier.journalThe Journal of hospital infectionen_GB
dc.description.provinceLeinster
html.description.abstractStaphylococcus aureus bloodstream infections (BSI) are a significant cause of morbidity and mortality in haemodialysis patients. This study describes a 12-year retrospective review of S. aureus BSI in a large haemodialysis centre in a tertiary referral hospital. The overall rate of S. aureus BSI was 17.9 per 100 patient-years (range 9.7-36.8). The rate of meticillin-resistant S. aureus (MRSA) BSI was 5.6 per 100 patient-years (range 0.9-13.8). Infective complications occurred in 11% of episodes, the most common being infective endocarditis (7.6%). Ten percent of patients died within 30 days of S. aureus being isolated from blood. Most cases of S. aureus BSI (83%) were related to vascular catheters. The provision of lower-risk vascular access, such as arteriovenous fistulae, and reduced use of intravascular catheters should be priorities in all haemodialysis units. Where alternative vascular access cannot be established, interventions to reduce the risk of catheter-related infections should be implemented to reduce morbidity and mortality in this vulnerable patient group.


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