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    Blood carbon dioxide levels and adverse outcome in neonatal hypoxic-ischemic encephalopathy.

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    Authors
    Nadeem, Montasser
    Murray, Deirdre
    Boylan, Geraldine
    Dempsey, Eugene M
    Ryan, C Anthony
    Affiliation
    Neonatal Intensive Care Unit, Cork University Maternity Hospital, Cork, Ireland.
    Issue Date
    2012-01-31T16:42:11Z
    MeSH
    Carbon Dioxide/*adverse effects/*blood
    Female
    Humans
    Hypercapnia/blood
    Hypocapnia/blood
    Hypoxia-Ischemia, Brain/*blood
    Infant, Newborn
    Male
    Pregnancy
    *Pregnancy Complications
    Pregnancy Outcome
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    Citation
    Am J Perinatol. 2010 May;27(5):361-5. Epub 2009 Dec 10.
    Journal
    American journal of perinatology
    URI
    http://hdl.handle.net/10147/206246
    DOI
    10.1055/s-0029-1243309
    PubMed ID
    20013576
    Abstract
    We investigated pCO(2) patterns and the relationship between pCO(2) levels and neurodevelopmental outcome in term infants with hypoxic-ischemic encephalopathy. Blood gases during the first 72 hours of life were collected from 52 infants with hypoxic-ischemic encephalopathy. Moderate hypocapnia (pCO(2) <3.3 kPa), severe hypocapnia (pCO(2) <2.6 kPa), and hypercapnia (pCO(2) >6.6 kPa) were correlated to neurodevelopmental outcome at 24 months. Normocapnia was documented in 416/551 (75.5%) of samples and was present during the entire 72 hours in only 6 out of 52 infants. Mean (standard deviation) pCO(2) values did not differ between infants with normal and abnormal outcomes: 5.43 (2.4) and 5.41 (2.03), respectively. There was no significant association between moderate hypocapnia, severe hypocapnia, or hypercapnia and adverse outcome (odds ratio [OR] = 1.84, 95% confidence interval [CI] = 0.49 to 6.89; OR = 3.16, CI = 0.14 to 28.45; and OR = 1.07, CI = 0.24 to 5.45, respectively). In conclusion, only one in nine newborns had normocapnia throughout the first 72 hours. Severe hypocapnia was rare and occurred only in ventilated babies. Hypercapnia and hypocapnia in infants with hypoxic-ischemic encephalopathy during the first 72 hours of life were not associated with adverse outcome.
    Language
    eng
    ISSN
    1098-8785 (Electronic)
    0735-1631 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1055/s-0029-1243309
    Scopus Count
    Collections
    Cork University Maternity Hospital

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