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dc.contributor.authorKhashan, Ali S
dc.contributor.authorKenny, Louise C
dc.contributor.authorMcNamee, Roseanne
dc.contributor.authorMortensen, Preben B
dc.contributor.authorPedersen, Marianne G
dc.contributor.authorMcCarthy, Fergus P
dc.contributor.authorHenriksen, Tine B
dc.date.accessioned2012-01-31T16:43:41Z
dc.date.available2012-01-31T16:43:41Z
dc.date.issued2012-01-31T16:43:41Z
dc.identifier.citationPaediatr Perinat Epidemiol. 2010 Jul 1;24(4):363-9.en_GB
dc.identifier.issn1365-3016 (Electronic)en_GB
dc.identifier.issn0269-5022 (Linking)en_GB
dc.identifier.pmid20618726en_GB
dc.identifier.doi10.1111/j.1365-3016.2010.01125.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/206241
dc.description.abstractThere is conflicting evidence regarding the effect of coeliac disease (CD) in the father on birthweight and preterm birth. We investigated the association between paternal CD and birthweight and preterm birth. Medical records of all singleton live-born children in Denmark between 1 January 1979 and 31 December 2004 were linked to information about parents' diseases. Fathers who were diagnosed with CD were then identified. Fathers with CD were considered treated if they were diagnosed before pregnancy and untreated if they were diagnosed after the date of conception. The outcome measures were: birthweight, small-for-gestational age (birthweight<10th centile for gestational age) and preterm birth (<37 weeks). We compared the offspring of men without CD (n = 1 472 352) and offspring of those with CD [untreated (n = 138) and treated (n = 473)]. There was no significant association between untreated CD in the father and birthweight (adjusted mean difference = -3 g; [95% CI -46, 40]) or preterm birth (adjusted odds ratio (OR) = 0.86, [95% CI 0.53, 1.37]) (compared with no CD). There was some evidence for an association between treated paternal CD and birthweight (adjusted mean difference = -81 g; [95% CI -161, -3]), but not preterm birth (adjusted OR = 1.76, [95% CI 0.95, 3.26]). Untreated paternal CD was not associated with an increased risk of reduced birthweight, or of preterm birth. There was some evidence that diagnosis and presumed treatment of paternal CD with a gluten-free diet is associated with reduced birthweight.
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.mesh*Birth Weighten_GB
dc.subject.meshCeliac Disease/diet therapy/*epidemiologyen_GB
dc.subject.meshDenmark/epidemiologyen_GB
dc.subject.meshDiet, Gluten-Freeen_GB
dc.subject.mesh*Fathersen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfanten_GB
dc.subject.meshMaleen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshPregnancy Outcomeen_GB
dc.subject.meshPremature Birth/*epidemiologyen_GB
dc.subject.meshYoung Adulten_GB
dc.titleUndiagnosed coeliac disease in a father does not influence birthweight and preterm birth.en_GB
dc.contributor.departmentAnu Research Centre, Department of Obstetrics and Gynaecology, University College, Cork, Cork University Maternity Hospital, Ireland. a.khashan@ucc.ieen_GB
dc.identifier.journalPaediatric and perinatal epidemiologyen_GB
dc.description.provinceMunster
html.description.abstractThere is conflicting evidence regarding the effect of coeliac disease (CD) in the father on birthweight and preterm birth. We investigated the association between paternal CD and birthweight and preterm birth. Medical records of all singleton live-born children in Denmark between 1 January 1979 and 31 December 2004 were linked to information about parents' diseases. Fathers who were diagnosed with CD were then identified. Fathers with CD were considered treated if they were diagnosed before pregnancy and untreated if they were diagnosed after the date of conception. The outcome measures were: birthweight, small-for-gestational age (birthweight<10th centile for gestational age) and preterm birth (<37 weeks). We compared the offspring of men without CD (n = 1 472 352) and offspring of those with CD [untreated (n = 138) and treated (n = 473)]. There was no significant association between untreated CD in the father and birthweight (adjusted mean difference = -3 g; [95% CI -46, 40]) or preterm birth (adjusted odds ratio (OR) = 0.86, [95% CI 0.53, 1.37]) (compared with no CD). There was some evidence for an association between treated paternal CD and birthweight (adjusted mean difference = -81 g; [95% CI -161, -3]), but not preterm birth (adjusted OR = 1.76, [95% CI 0.95, 3.26]). Untreated paternal CD was not associated with an increased risk of reduced birthweight, or of preterm birth. There was some evidence that diagnosis and presumed treatment of paternal CD with a gluten-free diet is associated with reduced birthweight.


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