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    Mast cells, peptides and cardioprotection - an unlikely marriage?

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    Authors
    Walsh, S K
    Kane, K A
    Wainwright, C L
    Affiliation
    Anu Research Centre, Department of Obstetrics & Gynaecology, University College, Cork, Cork University Maternity Hospital, Cork, Ireland.
    Issue Date
    2012-01-31T16:42:19Z
    MeSH
    Animals
    *Cardiotonic Agents
    Cell Degranulation
    Heart Diseases/pathology/*physiopathology
    Humans
    Mast Cells/*physiology
    Myocardial Ischemia/pathology/physiopathology
    Myocardium/pathology
    Neuropeptides/*pharmacology/*physiology
    
    Metadata
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    Citation
    Auton Autacoid Pharmacol. 2009 Jul;29(3):73-84.
    Journal
    Autonomic & autacoid pharmacology
    URI
    http://hdl.handle.net/10147/206240
    DOI
    10.1111/j.1474-8673.2009.00436.x
    PubMed ID
    19566747
    Abstract
    1 Mast cells have classically been regarded as the 'bad guys' in the setting of acute myocardial ischaemia, where their released contents are believed to contribute both to tissue injury and electrical disturbances resulting from ischaemia. Recent evidence suggests, however, that if mast cell degranulation occurs in advance of ischaemia onset, this may be cardioprotective by virtue of the depletion of mast cell contents that can no longer act as instruments of injury when the tissue becomes ischaemic. 2 Many peptides, such as ET-1, adrenomedullin, relaxin and atrial natriuretic peptide, have been demonstrated to be cardioprotective when given prior to the onset of myocardial ischaemia, although their physiological functions are varied and the mechanisms of their cardioprotective actions appear to be diverse and often ill defined. However, one common denominator that is emerging is the ability of these peptides to modulate mast cell degranulation, raising the possibility that peptide-induced mast cell degranulation or stabilization may hold the key to a common mechanism of their cardioprotection. 3 The aim of this review was to consolidate the evidence implying that mast cell degranulation could play both a detrimental and protective role in myocardial ischaemia, depending upon when it occurs, and that this may underlie the cardioprotective effects of a range of diverse peptides that exerts physiological effects within the cardiovascular system.
    Language
    eng
    ISSN
    1474-8673 (Electronic)
    1474-8665 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1474-8673.2009.00436.x
    Scopus Count
    Collections
    Cork University Maternity Hospital

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