Show simple item record

dc.contributor.authorDempsey, E M
dc.contributor.authorBarrington, K J
dc.date.accessioned2012-01-31T16:42:45Z
dc.date.available2012-01-31T16:42:45Z
dc.date.issued2012-01-31T16:42:45Z
dc.identifier.citationClin Perinatol. 2009 Mar;36(1):75-85.en_GB
dc.identifier.issn1557-9840 (Electronic)en_GB
dc.identifier.issn0095-5108 (Linking)en_GB
dc.identifier.pmid19161866en_GB
dc.identifier.doi10.1016/j.clp.2008.09.003en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206237
dc.description.abstractA large proportion of very preterm infants receive treatment for hypotension. The definition of hypotension is unclear, and, currently, there is no evidence that treating it improves outcomes or, indeed, which treatment to choose among the available alternatives. Assessment of circulatory adequacy of the preterm infant requires a careful clinical assessment and may also require ancillary investigations. The most commonly used interventions, fluid boluses and dopamine, are problematic: fluid boluses are statistically associated with worse clinical outcomes and may not even increase blood pressure, whereas dopamine increases blood pressure mostly by causing vasoconstriction and may decrease perfusion. For neither intervention is there any reliable data showing clinical benefit. Prospective trials of intervention for hypotension and circulatory compromise are urgently required.
dc.language.isoengen_GB
dc.subject.meshCardiotonic Agents/therapeutic useen_GB
dc.subject.meshFluid Therapyen_GB
dc.subject.meshGlucocorticoids/therapeutic useen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHypotension/*therapyen_GB
dc.subject.meshInfant, Newbornen_GB
dc.subject.meshInfant, Prematureen_GB
dc.subject.meshInfant, Premature, Diseases/*therapyen_GB
dc.subject.meshShock/*therapyen_GB
dc.titleEvaluation and treatment of hypotension in the preterm infant.en_GB
dc.contributor.departmentDepartment of Neonatology, Cork University Maternity Hospital, Cork, Ireland.en_GB
dc.identifier.journalClinics in perinatologyen_GB
dc.description.provinceMunster
html.description.abstractA large proportion of very preterm infants receive treatment for hypotension. The definition of hypotension is unclear, and, currently, there is no evidence that treating it improves outcomes or, indeed, which treatment to choose among the available alternatives. Assessment of circulatory adequacy of the preterm infant requires a careful clinical assessment and may also require ancillary investigations. The most commonly used interventions, fluid boluses and dopamine, are problematic: fluid boluses are statistically associated with worse clinical outcomes and may not even increase blood pressure, whereas dopamine increases blood pressure mostly by causing vasoconstriction and may decrease perfusion. For neither intervention is there any reliable data showing clinical benefit. Prospective trials of intervention for hypotension and circulatory compromise are urgently required.


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record