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    Therapeutic implications of manipulating and mining the microbiota.

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    Authors
    Shanahan, Fergus
    Affiliation
    Department of Medicine, Alimentary Pharmabiotic Centre, Clinical Science Building, Cork University Hospital and University College Cork, Cork, Ireland. f.shanahan@ucc.ie
    Issue Date
    2009-09-01
    MeSH
    Animals
    Humans
    Intestinal Diseases
    Intestines
    Metagenome
    Models, Biological
    Probiotics
    
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    Show full item record
    Citation
    Therapeutic implications of manipulating and mining the microbiota. 2009, 587 (Pt 17):4175-9 J. Physiol. (Lond.)
    Journal
    The Journal of physiology
    URI
    http://hdl.handle.net/10147/201331
    DOI
    10.1113/jphysiol.2009.174649
    PubMed ID
    19505978
    Additional Links
    http://jp.physoc.org/content/587/17/4175.full.pdf+html
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754358/pdf/tjp0587-4175.pdf
    Abstract
    The gut microbiota is increasingly recognized as a health asset but occasionally is a contributor to the pathogenesis of both gastrointestinal and certain extra-intestinal disorders. This is driving research interest, the pace of which has been greatly facilitated by new molecular technologies for studying mixed microbial populations, including the non-cultivable sector. In addition, it appears that elements of a modern lifestyle such as diet, domestic hygiene, urbanization, antibiotic usage and family size, may represent proxy markers of environmental influence on the composition of the microbiota colonizing the host in early life. While manipulation of the microbiota has become a therapeutic strategy in certain clinical disorders, the prospect of mining host-microbe-dietary interactions for novel drug discovery may become an even more intriguing reality.
    Item Type
    Article
    Language
    en
    ISSN
    1469-7793
    ae974a485f413a2113503eed53cd6c53
    10.1113/jphysiol.2009.174649
    Scopus Count
    Collections
    Cork University Hospital

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