Therapeutic implications of manipulating and mining the microbiota.
AffiliationDepartment of Medicine, Alimentary Pharmabiotic Centre, Clinical Science Building, Cork University Hospital and University College Cork, Cork, Ireland. email@example.com
MetadataShow full item record
CitationTherapeutic implications of manipulating and mining the microbiota. 2009, 587 (Pt 17):4175-9 J. Physiol. (Lond.)
JournalThe Journal of physiology
AbstractThe gut microbiota is increasingly recognized as a health asset but occasionally is a contributor to the pathogenesis of both gastrointestinal and certain extra-intestinal disorders. This is driving research interest, the pace of which has been greatly facilitated by new molecular technologies for studying mixed microbial populations, including the non-cultivable sector. In addition, it appears that elements of a modern lifestyle such as diet, domestic hygiene, urbanization, antibiotic usage and family size, may represent proxy markers of environmental influence on the composition of the microbiota colonizing the host in early life. While manipulation of the microbiota has become a therapeutic strategy in certain clinical disorders, the prospect of mining host-microbe-dietary interactions for novel drug discovery may become an even more intriguing reality.
- The world within--impact of the intestinal micobiota on whole body physiology and pathophysiology.
- Authors: Barrett KE
- Issue date: 2009 Sep 1
- Mechanisms of action of probiotics in intestinal diseases.
- Authors: O'Hara AM, Shanahan F
- Issue date: 2007 Jan 10
- Intestinal microbiota in health and disease: role of bifidobacteria in gut homeostasis.
- Authors: Tojo R, Suárez A, Clemente MG, de los Reyes-Gavilán CG, Margolles A, Gueimonde M, Ruas-Madiedo P
- Issue date: 2014 Nov 7
- The normal intestinal microbiota.
- Authors: Marchesi J, Shanahan F
- Issue date: 2007 Oct
- Functions of intestinal microflora in children.
- Authors: Buccigrossi V, Nicastro E, Guarino A
- Issue date: 2013 Jan