Nitric oxide index is not a predictor of cognitive dysfunction following laparotomy.
Name:
Publisher version
Affiliation
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Ireland. ctwomey@ualberta.ca <ctwomey@ualberta.ca>Issue Date
2010-02MeSH
Biological MarkersCognition Disorders
Female
Humans
Laparotomy
Male
Middle Aged
Nitric Oxide
Postoperative Complications
Predictive Value of TestsProspective Studies
Metadata
Show full item recordCitation
Nitric oxide index is not a predictor of cognitive dysfunction following laparotomy. 2010, 22 (1):22-8 J Clin AnesthJournal
Journal of clinical anesthesiaDOI
10.1016/j.jclinane.2009.02.011PubMed ID
20206847Abstract
To determine the associations between postoperative cognitive dysfunction (POCD) and plasma concentrations of stable nitric oxide products [nitric oxide index (NOi)].Prospective study.
Academic hospital.
28 ASA physical status I, II, and III physical status patients undergoing major non-cardiac surgery.
Cognitive assessment was performed preoperatively and postoperatively at 4 days (early) and 6 weeks (late).
Serial measurements of plasma NOi were recorded.
Early POCD with a deficit in one cognitive domain was present in 18 patients (64%), and in 8 patients (28%) with deficits in two or more cognitive domains. Late POCD was evident in three patients (20%) who had a deficit in one domain. Eight patients were lost to late follow-up. There was no difference in baseline or subsequent serum concentrations of NOi between those who showed early and late POCD and those who showed no POCD.
Factors other than nitric oxide-mediated injury is responsible for POCD following major non-cardiac surgery.