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    Nitric oxide index is not a predictor of cognitive dysfunction following laparotomy.

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    Authors
    Twomey, Ciaran
    Corrigan, Mark
    Burlacu, Crina
    Butler, Mark
    Iohom, Gabriella
    Shorten, George
    Affiliation
    Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Ireland. ctwomey@ualberta.ca <ctwomey@ualberta.ca>
    Issue Date
    2010-02
    MeSH
    Biological Markers
    Cognition Disorders
    Female
    Humans
    Laparotomy
    Male
    Middle Aged
    Nitric Oxide
    Postoperative Complications
    Predictive Value of Tests
    Prospective Studies
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    Citation
    Nitric oxide index is not a predictor of cognitive dysfunction following laparotomy. 2010, 22 (1):22-8 J Clin Anesth
    Journal
    Journal of clinical anesthesia
    URI
    http://hdl.handle.net/10147/201313
    DOI
    10.1016/j.jclinane.2009.02.011
    PubMed ID
    20206847
    Abstract
    To determine the associations between postoperative cognitive dysfunction (POCD) and plasma concentrations of stable nitric oxide products [nitric oxide index (NOi)].
    Prospective study.
    Academic hospital.
    28 ASA physical status I, II, and III physical status patients undergoing major non-cardiac surgery.
    Cognitive assessment was performed preoperatively and postoperatively at 4 days (early) and 6 weeks (late).
    Serial measurements of plasma NOi were recorded.
    Early POCD with a deficit in one cognitive domain was present in 18 patients (64%), and in 8 patients (28%) with deficits in two or more cognitive domains. Late POCD was evident in three patients (20%) who had a deficit in one domain. Eight patients were lost to late follow-up. There was no difference in baseline or subsequent serum concentrations of NOi between those who showed early and late POCD and those who showed no POCD.
    Factors other than nitric oxide-mediated injury is responsible for POCD following major non-cardiac surgery.
    Item Type
    Article
    Language
    en
    ISSN
    1873-4529
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jclinane.2009.02.011
    Scopus Count
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    Cork University Hospital

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