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    Longitudinal validity and responsiveness of the Food Allergy Quality of Life Questionnaire - Parent Form in children 0-12 years following positive and negative food challenges.

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    Authors
    DunnGalvin, A
    Cullinane, C
    Daly, D A
    Flokstra-de Blok, B M J
    Dubois, A E J
    Hourihane, J O'B
    Affiliation
    Department of Paediatrics and Child Health, Clinical Investigation Unit, Cork University Hospital, University College, Cork, Ireland. a.dunngalvin@ucc.ie
    Issue Date
    2010-03
    MeSH
    Child
    Child, Preschool
    Female
    Food Hypersensitivity
    Humans
    Infant
    Infant, Newborn
    Longitudinal Studies
    Male
    Parents
    Quality of Life
    Questionnaires
    Reproducibility of Results
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    Citation
    Longitudinal validity and responsiveness of the Food Allergy Quality of Life Questionnaire - Parent Form in children 0-12 years following positive and negative food challenges. 2010, 40 (3):476-85 Clin. Exp. Allergy
    Journal
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
    URI
    http://hdl.handle.net/10147/201312
    DOI
    10.1111/j.1365-2222.2010.03454.x
    PubMed ID
    20210816
    Abstract
    There are no published studies of longitudinal health-related quality of life (HRQL) assessments of food-allergic children using a disease-specific measure.
    This study assessed the longitudinal measurement properties of the Food Allergy Quality of Life Questionnaire - Parent Form (FAQLQ-PF) in a sample of children undergoing food challenge.
    Parents of children 0-12 years completed the FAQLQ-PF and the Food Allergy Independent Measure (FAIM) pre-challenge and at 2 and 6 months post food challenge. In order to evaluate longitudinal validity, differences between Group A (positive challenge) and Group B (negative challenge) were expected over time. We computed correlation coefficients between change scores in the FAQLQ-PF and change scores in the FAIM. To determine the minimally important difference (MID), we used distributional criterion and effect size approaches. A logistic regression model profiled those children falling below this point.
    Eighty-two children underwent a challenge (42 positive; 40 negative). Domains and total score improved significantly at pos-challenge time-points for both groups (all P<0.05). Sensitivity was demonstrated by significant differences between positive and negative groups at 6 months [F(2, 59)=6.221, P<0.003] and by differing improvement on relevant subscales (P<0.05). MID was 0.45 on a seven-point response scale. Poorer quality of life at baseline increased the odds by over 2.0 of no improvement in HRQL scores 6-month time-point. General maternal health (OR 1.252), number of foods avoided (OR 1.369) and children >9 years (OR 1.173) were also predictors. The model correctly identified 84% of cases below MID.
    The FAQLQ-PF is sensitive to change, and has excellent longitudinal reliability and validity in a food-allergic patient population. The standard error of measurement value of 0.5 points as a threshold for meaningful change in HRQL questionnaires was confirmed. The FAQLQ-PF may be used to identify problems in children, to assess the effectiveness of clinical trials or interventions, and to guide the development of regulatory policies.
    Item Type
    Article
    Language
    en
    ISSN
    1365-2222
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2222.2010.03454.x
    Scopus Count
    Collections
    Cork University Hospital

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