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dc.contributor.authorO'Connor, Owen J
dc.contributor.authorVandeleur, Moya
dc.contributor.authorMcGarrigle, Anne Marie
dc.contributor.authorMoore, Niamh
dc.contributor.authorMcWilliams, Sebastian R
dc.contributor.authorMcSweeney, Sean E
dc.contributor.authorO'Neill, Michael
dc.contributor.authorNi Chroinin, Muireann
dc.contributor.authorMaher, Michael M
dc.date.accessioned2012-01-10T14:11:28Z
dc.date.available2012-01-10T14:11:28Z
dc.date.issued2010-12
dc.identifier.citationDevelopment of low-dose protocols for thin-section CT assessment of cystic fibrosis in pediatric patients. 2010, 257 (3):820-9 Radiologyen
dc.identifier.issn1527-1315
dc.identifier.pmid20876388
dc.identifier.doi10.1148/radiol.10100278
dc.identifier.urihttp://hdl.handle.net/10147/201309
dc.description.abstractTo develop low-dose thin-section computed tomographic (CT) protocols for assessment of cystic fibrosis (CF) in pediatric patients and determine the clinical usefulness thereof compared with chest radiography.
dc.description.abstractAfter institutional review board approval and informed consent from patients or guardians were obtained, 14 patients with CF and 11 patients without CF (16 male, nine female; mean age, 12.6 years ± 5.4 [standard deviation]; range, 3.5-25 years) who underwent imaging for clinical reasons underwent low-dose thin-section CT. Sections 1 mm thick (protocol A) were used in 10 patients, and sections 0.5 mm thick (protocol B) were used in 15 patients at six levels at 120 kVp and 30-50 mA. Image quality and diagnostic acceptability were scored qualitatively and quantitatively by two radiologists who also quantified disease severity at thin-section CT and chest radiography. Effective doses were calculated by using a CT dosimetry calculator.
dc.description.abstractLow-dose thin-section CT was performed with mean effective doses of 0.19 mSv ± 0.03 for protocol A and 0.14 mSv ± 0.04 for protocol B (P < .005). Diagnostic acceptability and depiction of bronchovascular structures at lung window settings were graded as almost excellent for both protocols, but protocol B was inferior to protocol A for mediastinal assessment (P < .02). Patients with CF had moderate lung disease with a mean Bhalla score of 9.2 ± 5.3 (range, 0-19), compared with that of patients without CF (1.1 ± 1.4; P < .001). There was excellent correlation between thin-section CT and chest radiography (r = 0.88-0.92; P < .001).
dc.description.abstractLow-dose thin-section CT can be performed at lower effective doses than can standard CT, approaching those of chest radiography. Low-dose thin-section CT could be appropriate for evaluating bronchiectasis in pediatric patients, yielding appropriate information about lung parenchyma and bronchovascular structures.
dc.language.isoenen
dc.relation.urlhttp://radiology.rsna.org/content/257/3/820.full.pdf+htmlen
dc.subject.meshAdolescent
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshCystic Fibrosis
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshProspective Studies
dc.subject.meshRadiation Dosage
dc.subject.meshRadiography, Thoracic
dc.subject.meshStatistics, Nonparametric
dc.subject.meshTomography, X-Ray Computed
dc.subject.meshYoung Adult
dc.titleDevelopment of low-dose protocols for thin-section CT assessment of cystic fibrosis in pediatric patients.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiology, University College Cork and Cork University Hospital, Wilton, Cork 1111, Ireland.en
dc.identifier.journalRadiologyen
dc.description.provinceMunster
html.description.abstractTo develop low-dose thin-section computed tomographic (CT) protocols for assessment of cystic fibrosis (CF) in pediatric patients and determine the clinical usefulness thereof compared with chest radiography.
html.description.abstractAfter institutional review board approval and informed consent from patients or guardians were obtained, 14 patients with CF and 11 patients without CF (16 male, nine female; mean age, 12.6 years ± 5.4 [standard deviation]; range, 3.5-25 years) who underwent imaging for clinical reasons underwent low-dose thin-section CT. Sections 1 mm thick (protocol A) were used in 10 patients, and sections 0.5 mm thick (protocol B) were used in 15 patients at six levels at 120 kVp and 30-50 mA. Image quality and diagnostic acceptability were scored qualitatively and quantitatively by two radiologists who also quantified disease severity at thin-section CT and chest radiography. Effective doses were calculated by using a CT dosimetry calculator.
html.description.abstractLow-dose thin-section CT was performed with mean effective doses of 0.19 mSv ± 0.03 for protocol A and 0.14 mSv ± 0.04 for protocol B (P < .005). Diagnostic acceptability and depiction of bronchovascular structures at lung window settings were graded as almost excellent for both protocols, but protocol B was inferior to protocol A for mediastinal assessment (P < .02). Patients with CF had moderate lung disease with a mean Bhalla score of 9.2 ± 5.3 (range, 0-19), compared with that of patients without CF (1.1 ± 1.4; P < .001). There was excellent correlation between thin-section CT and chest radiography (r = 0.88-0.92; P < .001).
html.description.abstractLow-dose thin-section CT can be performed at lower effective doses than can standard CT, approaching those of chest radiography. Low-dose thin-section CT could be appropriate for evaluating bronchiectasis in pediatric patients, yielding appropriate information about lung parenchyma and bronchovascular structures.


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