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    Development of low-dose protocols for thin-section CT assessment of cystic fibrosis in pediatric patients.

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    Authors
    O'Connor, Owen J
    Vandeleur, Moya
    McGarrigle, Anne Marie
    Moore, Niamh
    McWilliams, Sebastian R
    McSweeney, Sean E
    O'Neill, Michael
    Ni Chroinin, Muireann
    Maher, Michael M
    Affiliation
    Department of Radiology, University College Cork and Cork University Hospital, Wilton, Cork 1111, Ireland.
    Issue Date
    2010-12
    MeSH
    Adolescent
    Child
    Child, Preschool
    Cystic Fibrosis
    Female
    Humans
    Male
    Prospective Studies
    Radiation Dosage
    Radiography, Thoracic
    Statistics, Nonparametric
    Tomography, X-Ray Computed
    Young Adult
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    Citation
    Development of low-dose protocols for thin-section CT assessment of cystic fibrosis in pediatric patients. 2010, 257 (3):820-9 Radiology
    Journal
    Radiology
    URI
    http://hdl.handle.net/10147/201309
    DOI
    10.1148/radiol.10100278
    PubMed ID
    20876388
    Additional Links
    http://radiology.rsna.org/content/257/3/820.full.pdf+html
    Abstract
    To develop low-dose thin-section computed tomographic (CT) protocols for assessment of cystic fibrosis (CF) in pediatric patients and determine the clinical usefulness thereof compared with chest radiography.
    After institutional review board approval and informed consent from patients or guardians were obtained, 14 patients with CF and 11 patients without CF (16 male, nine female; mean age, 12.6 years ± 5.4 [standard deviation]; range, 3.5-25 years) who underwent imaging for clinical reasons underwent low-dose thin-section CT. Sections 1 mm thick (protocol A) were used in 10 patients, and sections 0.5 mm thick (protocol B) were used in 15 patients at six levels at 120 kVp and 30-50 mA. Image quality and diagnostic acceptability were scored qualitatively and quantitatively by two radiologists who also quantified disease severity at thin-section CT and chest radiography. Effective doses were calculated by using a CT dosimetry calculator.
    Low-dose thin-section CT was performed with mean effective doses of 0.19 mSv ± 0.03 for protocol A and 0.14 mSv ± 0.04 for protocol B (P < .005). Diagnostic acceptability and depiction of bronchovascular structures at lung window settings were graded as almost excellent for both protocols, but protocol B was inferior to protocol A for mediastinal assessment (P < .02). Patients with CF had moderate lung disease with a mean Bhalla score of 9.2 ± 5.3 (range, 0-19), compared with that of patients without CF (1.1 ± 1.4; P < .001). There was excellent correlation between thin-section CT and chest radiography (r = 0.88-0.92; P < .001).
    Low-dose thin-section CT can be performed at lower effective doses than can standard CT, approaching those of chest radiography. Low-dose thin-section CT could be appropriate for evaluating bronchiectasis in pediatric patients, yielding appropriate information about lung parenchyma and bronchovascular structures.
    Item Type
    Article
    Language
    en
    ISSN
    1527-1315
    ae974a485f413a2113503eed53cd6c53
    10.1148/radiol.10100278
    Scopus Count
    Collections
    Cork University Hospital

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