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    The evolving role of taurolidine in cancer therapy.

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    Authors
    Neary, Peter M
    Hallihan, Patrick
    Wang, Jiang H
    Pfirrmann, Rolf W
    Bouchier-Hayes, David J
    Redmond, Henry P
    Affiliation
    Department of Academic Surgery, University College Cork, Cork University Hospital, Wilton, Cork, Ireland. peterneary@hotmail.com
    Issue Date
    2010-04
    MeSH
    Animals
    Antineoplastic Agents
    Humans
    Neoplasms
    Taurine
    Thiadiazines
    
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    Citation
    The evolving role of taurolidine in cancer therapy. 2010, 17 (4):1135-43 Ann. Surg. Oncol.
    Journal
    Annals of surgical oncology
    URI
    http://hdl.handle.net/10147/201260
    DOI
    10.1245/s10434-009-0867-9
    PubMed ID
    20039217
    Abstract
    BACKGROUND AND DESIGN: Taurolidine consists of two taurinamide rings derived from the naturally occurring amino acid taurine. It has been utilized to prevent adhesions, as an antimicrobial, and as an anti-inflammatory agent. More recently, it has been found to exert antineoplastic activity. We reviewed the literature regarding taurolidine and its role in cancer treatment. RESULTS AND CONCLUSION: Taurolidine induces cancer cell death through a variety of mechanisms. Even now, all the antineoplastic pathways it employs are not completely elucidated. It has been shown to enhance apoptosis, inhibit angiogenesis, reduce tumor adherence, downregulate proinflammatory cytokine release, and stimulate anticancer immune regulation following surgical trauma. Apoptosis is activated through both a mitochondrial cytochrome-c-dependent mechanism and an extrinsic direct pathway. A lot of in vitro and animal data support taurolidine's tumoricidal action. Taurolidine has been used as an antimicrobial agent in the clinical setting since the 1970s and thus far appears nontoxic. The nontoxic nature of taurolidine makes it a favorable option compared with current chemotherapeutic regimens. Few published clinical studies exist evaluating the role of taurolidine as a chemotherapeutic agent. The literature lacks a gold-standard level 1 randomized clinical trial to evaluate taurolidine's potential antineoplastic benefits. However, these trials are currently underway. Such randomized control studies are vital to clarify the role of taurolidine in modern cancer treatment.
    Item Type
    Article
    Language
    en
    ISSN
    1534-4681
    ae974a485f413a2113503eed53cd6c53
    10.1245/s10434-009-0867-9
    Scopus Count
    Collections
    Cork University Hospital

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