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dc.contributor.authorSattar, N
dc.contributor.authorMurray, H M
dc.contributor.authorWelsh, P
dc.contributor.authorBlauw, G J
dc.contributor.authorBuckley, B M
dc.contributor.authorde Craen, A J
dc.contributor.authorFord, I
dc.contributor.authorForouhi, N G
dc.contributor.authorFreeman, D J
dc.contributor.authorJukema, J W
dc.contributor.authorMacfarlane, P W
dc.contributor.authorMurphy, M B
dc.contributor.authorPackard, C J
dc.contributor.authorStott, D J
dc.contributor.authorWestendorp, R G J
dc.contributor.authorShepherd, J
dc.date.accessioned2012-01-10T12:53:08Z
dc.date.available2012-01-10T12:53:08Z
dc.date.issued2009-02
dc.identifier.citationAre elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly. 2009, 52 (2):235-9 Diabetologiaen
dc.identifier.issn1432-0428
dc.identifier.pmid19030842
dc.identifier.doi10.1007/s00125-008-1217-3
dc.identifier.urihttp://hdl.handle.net/10147/201250
dc.descriptionAIMS/HYPOTHESIS: The aim of this prospective study was to determine whether circulating intercellular adhesion molecule (ICAM) 1, as a potential surrogate of 'endothelial activation', is more strongly associated with risk of vascular events than with incident diabetes. METHODS: We related baseline ICAM-1 levels to vascular events (866 CHD and stroke events in 5,685 participants) and incident diabetes (292 in 4,945 without baseline diabetes) in the elderly over 3.2 years of follow-up. RESULTS: ICAM-1 levels correlated positively with triacylglycerol but negatively with LDL- and HDL-cholesterol. ICAM-1 levels were higher in those who developed diabetes (388.6 +/- 1.42 vs 369.4 +/- 1.39 ng/ml [mean+/-SD], p = 0.011) and remained independently associated with new-onset diabetes (HR 1.84, 95% CI 1.26-2.69, p = 0.0015 per unit increase in log[ICAM-1] after adjusting for classical risk factors and C-reactive protein). By contrast, ICAM-1 levels were not significantly (p = 0.40) elevated in those who had an incident vascular event compared with those who remained event-free, and corresponding adjusted risk associations were null (HR 0.98, 95% CI 0.80-1.22, p = 0.89) in analyses adjusted for other risk factors. CONCLUSIONS/INTERPRETATION: We show that elevated ICAM-1 levels are associated with risk of incident diabetes in the elderly at risk, despite no association with incident cardiovascular disease risk. We suggest that perturbations in circulating ICAM-1 levels are aligned more towards diabetes risk.en
dc.description.abstractThe aim of this prospective study was to determine whether circulating intercellular adhesion molecule (ICAM) 1, as a potential surrogate of 'endothelial activation', is more strongly associated with risk of vascular events than with incident diabetes.
dc.description.abstractWe related baseline ICAM-1 levels to vascular events (866 CHD and stroke events in 5,685 participants) and incident diabetes (292 in 4,945 without baseline diabetes) in the elderly over 3.2 years of follow-up.
dc.description.abstractICAM-1 levels correlated positively with triacylglycerol but negatively with LDL- and HDL-cholesterol. ICAM-1 levels were higher in those who developed diabetes (388.6 +/- 1.42 vs 369.4 +/- 1.39 ng/ml [mean+/-SD], p = 0.011) and remained independently associated with new-onset diabetes (HR 1.84, 95% CI 1.26-2.69, p = 0.0015 per unit increase in log[ICAM-1] after adjusting for classical risk factors and C-reactive protein). By contrast, ICAM-1 levels were not significantly (p = 0.40) elevated in those who had an incident vascular event compared with those who remained event-free, and corresponding adjusted risk associations were null (HR 0.98, 95% CI 0.80-1.22, p = 0.89) in analyses adjusted for other risk factors.
dc.description.abstractWe show that elevated ICAM-1 levels are associated with risk of incident diabetes in the elderly at risk, despite no association with incident cardiovascular disease risk. We suggest that perturbations in circulating ICAM-1 levels are aligned more towards diabetes risk.
dc.language.isoenen
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshBlood Pressure
dc.subject.meshCholesterol
dc.subject.meshCholesterol, HDL
dc.subject.meshCholesterol, LDL
dc.subject.meshDiabetes Mellitus
dc.subject.meshEndothelium, Vascular
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHumans
dc.subject.meshHydroxymethylglutaryl-CoA Reductase Inhibitors
dc.subject.meshIncidence
dc.subject.meshIntercellular Adhesion Molecule-1
dc.subject.meshMale
dc.subject.meshMyocardial Infarction
dc.subject.meshPravastatin
dc.subject.meshPredictive Value of Tests
dc.subject.meshProspective Studies
dc.subject.meshRisk Factors
dc.subject.meshStroke
dc.subject.meshTime Factors
dc.titleAre elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly.en
dc.typeArticleen
dc.contributor.departmentFaculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, University Place, Glasgow G12 8TA, UK. nsattar@clinmed.gla.ac.uken
dc.identifier.journalDiabetologiaen
dc.description.provinceMunster
html.description.abstractThe aim of this prospective study was to determine whether circulating intercellular adhesion molecule (ICAM) 1, as a potential surrogate of 'endothelial activation', is more strongly associated with risk of vascular events than with incident diabetes.
html.description.abstractWe related baseline ICAM-1 levels to vascular events (866 CHD and stroke events in 5,685 participants) and incident diabetes (292 in 4,945 without baseline diabetes) in the elderly over 3.2 years of follow-up.
html.description.abstractICAM-1 levels correlated positively with triacylglycerol but negatively with LDL- and HDL-cholesterol. ICAM-1 levels were higher in those who developed diabetes (388.6 +/- 1.42 vs 369.4 +/- 1.39 ng/ml [mean+/-SD], p = 0.011) and remained independently associated with new-onset diabetes (HR 1.84, 95% CI 1.26-2.69, p = 0.0015 per unit increase in log[ICAM-1] after adjusting for classical risk factors and C-reactive protein). By contrast, ICAM-1 levels were not significantly (p = 0.40) elevated in those who had an incident vascular event compared with those who remained event-free, and corresponding adjusted risk associations were null (HR 0.98, 95% CI 0.80-1.22, p = 0.89) in analyses adjusted for other risk factors.
html.description.abstractWe show that elevated ICAM-1 levels are associated with risk of incident diabetes in the elderly at risk, despite no association with incident cardiovascular disease risk. We suggest that perturbations in circulating ICAM-1 levels are aligned more towards diabetes risk.


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