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    Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly.

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    Authors
    Sattar, N
    Murray, H M
    Welsh, P
    Blauw, G J
    Buckley, B M
    de Craen, A J
    Ford, I
    Forouhi, N G
    Freeman, D J
    Jukema, J W
    Macfarlane, P W
    Murphy, M B
    Packard, C J
    Stott, D J
    Westendorp, R G J
    Shepherd, J
    Show allShow less
    Affiliation
    Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, University Place, Glasgow G12 8TA, UK. nsattar@clinmed.gla.ac.uk
    Issue Date
    2009-02
    MeSH
    Aged
    Aged, 80 and over
    Blood Pressure
    Cholesterol
    Cholesterol, HDL
    Cholesterol, LDL
    Diabetes Mellitus
    Endothelium, Vascular
    Female
    Follow-Up Studies
    Humans
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Incidence
    Intercellular Adhesion Molecule-1
    Male
    Myocardial Infarction
    Pravastatin
    Predictive Value of Tests
    Prospective Studies
    Risk Factors
    Stroke
    Time Factors
    Show allShow less
    
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    Citation
    Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly. 2009, 52 (2):235-9 Diabetologia
    Journal
    Diabetologia
    URI
    http://hdl.handle.net/10147/201250
    DOI
    10.1007/s00125-008-1217-3
    PubMed ID
    19030842
    Abstract
    The aim of this prospective study was to determine whether circulating intercellular adhesion molecule (ICAM) 1, as a potential surrogate of 'endothelial activation', is more strongly associated with risk of vascular events than with incident diabetes.
    We related baseline ICAM-1 levels to vascular events (866 CHD and stroke events in 5,685 participants) and incident diabetes (292 in 4,945 without baseline diabetes) in the elderly over 3.2 years of follow-up.
    ICAM-1 levels correlated positively with triacylglycerol but negatively with LDL- and HDL-cholesterol. ICAM-1 levels were higher in those who developed diabetes (388.6 +/- 1.42 vs 369.4 +/- 1.39 ng/ml [mean+/-SD], p = 0.011) and remained independently associated with new-onset diabetes (HR 1.84, 95% CI 1.26-2.69, p = 0.0015 per unit increase in log[ICAM-1] after adjusting for classical risk factors and C-reactive protein). By contrast, ICAM-1 levels were not significantly (p = 0.40) elevated in those who had an incident vascular event compared with those who remained event-free, and corresponding adjusted risk associations were null (HR 0.98, 95% CI 0.80-1.22, p = 0.89) in analyses adjusted for other risk factors.
    We show that elevated ICAM-1 levels are associated with risk of incident diabetes in the elderly at risk, despite no association with incident cardiovascular disease risk. We suggest that perturbations in circulating ICAM-1 levels are aligned more towards diabetes risk.
    Item Type
    Article
    Language
    en
    ISSN
    1432-0428
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00125-008-1217-3
    Scopus Count
    Collections
    Cork University Hospital

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