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dc.contributor.authorGaensbauer, J T
dc.contributor.authorVandaleur, M
dc.contributor.authorO'Neil, M
dc.contributor.authorAltaf, A
dc.contributor.authorNí Chróinín, M
dc.date.accessioned2012-01-10T11:46:09Z
dc.date.available2012-01-10T11:46:09Z
dc.date.issued2009-05
dc.identifier.citationBCG protects toddlers during a tuberculosis outbreak. 2009, 94 (5):392-3 Arch. Dis. Child.en
dc.identifier.issn1468-2044
dc.identifier.pmid19190006
dc.identifier.doi10.1136/adc.2008.145755
dc.identifier.urihttp://hdl.handle.net/10147/201211
dc.descriptionIn 2007, an outbreak of tuberculosis occurred in a toddler population attending two child care centres in Cork, Ireland. Of 268 children exposed, 18 were eventually diagnosed with active tuberculosis. We present the initial clinical and radiographic characteristics of the active disease group. Mantoux testing was positive in only 66% of cases. All cases were either pulmonary or involved hilar adenopathy on chest radiograph; there were no cases of disseminated disease or meningitis. 24% of the exposed children had been previously vaccinated with BCG, and no case of active disease was found in this group (p = 0.016), suggesting a profound protective effect of BCG in this population. Our experience provides evidence supporting a protective effect of BCG against pulmonary disease in young children.en
dc.description.abstractIn 2007, an outbreak of tuberculosis occurred in a toddler population attending two child care centres in Cork, Ireland. Of 268 children exposed, 18 were eventually diagnosed with active tuberculosis. We present the initial clinical and radiographic characteristics of the active disease group. Mantoux testing was positive in only 66% of cases. All cases were either pulmonary or involved hilar adenopathy on chest radiograph; there were no cases of disseminated disease or meningitis. 24% of the exposed children had been previously vaccinated with BCG, and no case of active disease was found in this group (p = 0.016), suggesting a profound protective effect of BCG in this population. Our experience provides evidence supporting a protective effect of BCG against pulmonary disease in young children.
dc.language.isoenen
dc.subject.meshAdjuvants, Immunologic
dc.subject.meshBCG Vaccine
dc.subject.meshChild, Preschool
dc.subject.meshDisease Outbreaks
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunization Programs
dc.subject.meshIreland
dc.subject.meshMale
dc.subject.meshTuberculosis, Pulmonary
dc.titleBCG protects toddlers during a tuberculosis outbreak.en
dc.typeArticleen
dc.contributor.departmentDivision of Paediatrics, Cork University Hospital, Wilton Road, Wilton, Cork, Ireland. jgaens@u.washington.eduen
dc.identifier.journalArchives of disease in childhooden
dc.description.provinceMunster
html.description.abstractIn 2007, an outbreak of tuberculosis occurred in a toddler population attending two child care centres in Cork, Ireland. Of 268 children exposed, 18 were eventually diagnosed with active tuberculosis. We present the initial clinical and radiographic characteristics of the active disease group. Mantoux testing was positive in only 66% of cases. All cases were either pulmonary or involved hilar adenopathy on chest radiograph; there were no cases of disseminated disease or meningitis. 24% of the exposed children had been previously vaccinated with BCG, and no case of active disease was found in this group (p = 0.016), suggesting a profound protective effect of BCG in this population. Our experience provides evidence supporting a protective effect of BCG against pulmonary disease in young children.


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