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    BCG protects toddlers during a tuberculosis outbreak.

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    Authors
    Gaensbauer, J T
    Vandaleur, M
    O'Neil, M
    Altaf, A
    Ní Chróinín, M
    Affiliation
    Division of Paediatrics, Cork University Hospital, Wilton Road, Wilton, Cork, Ireland. jgaens@u.washington.edu
    Issue Date
    2009-05
    MeSH
    Adjuvants, Immunologic
    BCG Vaccine
    Child, Preschool
    Disease Outbreaks
    Female
    Humans
    Immunization Programs
    Ireland
    Male
    Tuberculosis, Pulmonary
    
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    Citation
    BCG protects toddlers during a tuberculosis outbreak. 2009, 94 (5):392-3 Arch. Dis. Child.
    Journal
    Archives of disease in childhood
    URI
    http://hdl.handle.net/10147/201211
    DOI
    10.1136/adc.2008.145755
    PubMed ID
    19190006
    Abstract
    In 2007, an outbreak of tuberculosis occurred in a toddler population attending two child care centres in Cork, Ireland. Of 268 children exposed, 18 were eventually diagnosed with active tuberculosis. We present the initial clinical and radiographic characteristics of the active disease group. Mantoux testing was positive in only 66% of cases. All cases were either pulmonary or involved hilar adenopathy on chest radiograph; there were no cases of disseminated disease or meningitis. 24% of the exposed children had been previously vaccinated with BCG, and no case of active disease was found in this group (p = 0.016), suggesting a profound protective effect of BCG in this population. Our experience provides evidence supporting a protective effect of BCG against pulmonary disease in young children.
    Item Type
    Article
    Language
    en
    ISSN
    1468-2044
    ae974a485f413a2113503eed53cd6c53
    10.1136/adc.2008.145755
    Scopus Count
    Collections
    Cork University Hospital

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