Affiliation
Division of Paediatrics, Cork University Hospital, Wilton Road, Wilton, Cork, Ireland. jgaens@u.washington.eduIssue Date
2009-05MeSH
Adjuvants, ImmunologicBCG Vaccine
Child, Preschool
Disease Outbreaks
Female
Humans
Immunization Programs
Ireland
Male
Tuberculosis, Pulmonary
Metadata
Show full item recordCitation
BCG protects toddlers during a tuberculosis outbreak. 2009, 94 (5):392-3 Arch. Dis. Child.Journal
Archives of disease in childhoodDOI
10.1136/adc.2008.145755PubMed ID
19190006Abstract
In 2007, an outbreak of tuberculosis occurred in a toddler population attending two child care centres in Cork, Ireland. Of 268 children exposed, 18 were eventually diagnosed with active tuberculosis. We present the initial clinical and radiographic characteristics of the active disease group. Mantoux testing was positive in only 66% of cases. All cases were either pulmonary or involved hilar adenopathy on chest radiograph; there were no cases of disseminated disease or meningitis. 24% of the exposed children had been previously vaccinated with BCG, and no case of active disease was found in this group (p = 0.016), suggesting a profound protective effect of BCG in this population. Our experience provides evidence supporting a protective effect of BCG against pulmonary disease in young children.Item Type
ArticleLanguage
enISSN
1468-2044ae974a485f413a2113503eed53cd6c53
10.1136/adc.2008.145755