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    Can mean platelet component be used as an index of platelet activity in stable coronary artery disease?

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    Authors
    Cooke, John
    Murphy, Tracy
    McFadden, Eugene
    O'Reilly, Mairead
    Cahill, Mary R
    Affiliation
    Mid-Western Regional Hospital, Dooradoyle, Limerick, Ireland.
    Issue Date
    2009-04
    MeSH
    Blood Platelets
    Case-Control Studies
    Coronary Angiography
    Coronary Artery Disease
    Female
    Flow Cytometry
    Humans
    Male
    Middle Aged
    P-Selectin
    Platelet Activation
    Platelet Count
    Prospective Studies
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    Citation
    Can mean platelet component be used as an index of platelet activity in stable coronary artery disease? 2009, 14 (2):111-4 Hematology
    Journal
    Hematology (Amsterdam, Netherlands)
    URI
    http://hdl.handle.net/10147/201000
    DOI
    10.1179/102453309X385160
    PubMed ID
    19298724
    Abstract
    Acute coronary syndrome is associated with intracoronary thrombosis secondary to platelet activation. Previous groups have investigated platelet activation in both stable and unstable vascular disease. Most measures of platelet activation are not routinely available or easily adaptable to large scale clinical use. Recently, measurement of the mean platelet component (MPC) has become part of the routine data provided by an automated full blood count analyser, the Advia 120. MPC measures platelet density which changes on platelet activation. Our objectives were to determine if platelet activation, as measured by MPC, is increased in patients with stable coronary artery disease (CAD) and to determine if MPC could be useful in differentiating people with stable CAD from controls on an everyday clinical basis. Three hundred and forty-five consecutive patients attending for elective coronary angiography had full blood count analysis and MPC measurement performed using an ADVIA-120 analyser. Three hundred and twenty-four were analysed in our final dataset. Two hundred and fifty-three (78%) had CAD. Patients with CAD were significantly (p<0.001) older than those without (63.8 versus 56.0 years). Results failed to demonstrate a difference (p=0.467) in MPC between patients with CAD and those with normal coronary arteries (25.8 versus 26.0). Likewise, there was no correlation between MPC and the severity of CAD (Kendall's tau b=-0.086, p=0.04). MPC is not a useful index of platelet activity in stable CAD when used in everyday clinical practice.
    Item Type
    Article
    Language
    en
    ISSN
    1607-8454
    ae974a485f413a2113503eed53cd6c53
    10.1179/102453309X385160
    Scopus Count
    Collections
    Cork University Hospital

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