Affiliation
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, Wilton, Cork, Ireland.Issue Date
2009-02MeSH
AnimalsHumans
Pain, Postoperative
Patient Education as Topic
Risk Factors
Metadata
Show full item recordCitation
When pain after surgery doesn't go away... 2009, 37 (Pt 1):318-22 Biochem. Soc. Trans.Journal
Biochemical Society transactionsDOI
10.1042/BST0370318PubMed ID
19143655Abstract
Chronic post-surgical pain is a common, under-recognized and important clinical problem which affects millions of patients worldwide. It results from a series of neuroplastic changes associated most commonly with peripheral nerve injury at the time of surgery. Predisposing factors include the type of surgery, pre-operative and acute post-operative pain intensity, and probably psychological (e.g. pain-catastrophizing) and genetic factors [e.g. GCH1 (GTP cyclohydrolase 1) haplotype]. Preventive measures which are currently available include selection of a minimally invasive surgical technique and an aggressive multimodal perioperative analgesic regimen. Very promising therapeutic agents which target the sensitization process are currently in development.Item Type
ArticleLanguage
enISSN
1470-8752ae974a485f413a2113503eed53cd6c53
10.1042/BST0370318
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