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    When pain after surgery doesn't go away...

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    Authors
    Burke, Siún
    Shorten, George D
    Affiliation
    Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, Wilton, Cork, Ireland.
    Issue Date
    2009-02
    MeSH
    Animals
    Humans
    Pain, Postoperative
    Patient Education as Topic
    Risk Factors
    
    Metadata
    Show full item record
    Citation
    When pain after surgery doesn't go away... 2009, 37 (Pt 1):318-22 Biochem. Soc. Trans.
    Journal
    Biochemical Society transactions
    URI
    http://hdl.handle.net/10147/200985
    DOI
    10.1042/BST0370318
    PubMed ID
    19143655
    Abstract
    Chronic post-surgical pain is a common, under-recognized and important clinical problem which affects millions of patients worldwide. It results from a series of neuroplastic changes associated most commonly with peripheral nerve injury at the time of surgery. Predisposing factors include the type of surgery, pre-operative and acute post-operative pain intensity, and probably psychological (e.g. pain-catastrophizing) and genetic factors [e.g. GCH1 (GTP cyclohydrolase 1) haplotype]. Preventive measures which are currently available include selection of a minimally invasive surgical technique and an aggressive multimodal perioperative analgesic regimen. Very promising therapeutic agents which target the sensitization process are currently in development.
    Item Type
    Article
    Language
    en
    ISSN
    1470-8752
    ae974a485f413a2113503eed53cd6c53
    10.1042/BST0370318
    Scopus Count
    Collections
    Cork University Hospital

    entitlement

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