AffiliationDepartment of Anaesthesia and Intensive Care Medicine, Cork University Hospital, Wilton, Cork, Ireland.
Patient Education as Topic
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CitationWhen pain after surgery doesn't go away... 2009, 37 (Pt 1):318-22 Biochem. Soc. Trans.
JournalBiochemical Society transactions
AbstractChronic post-surgical pain is a common, under-recognized and important clinical problem which affects millions of patients worldwide. It results from a series of neuroplastic changes associated most commonly with peripheral nerve injury at the time of surgery. Predisposing factors include the type of surgery, pre-operative and acute post-operative pain intensity, and probably psychological (e.g. pain-catastrophizing) and genetic factors [e.g. GCH1 (GTP cyclohydrolase 1) haplotype]. Preventive measures which are currently available include selection of a minimally invasive surgical technique and an aggressive multimodal perioperative analgesic regimen. Very promising therapeutic agents which target the sensitization process are currently in development.