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    Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis.

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    Authors
    Ji, G-R
    Yao, M
    Sun, C-Y
    Zhang, L
    Han, Z
    Affiliation
    Department of Orthopaedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. guangrongji2009@hotmail.com
    Issue Date
    2012-01-06T15:44:39Z
    MeSH
    Aged
    Aged, 80 and over
    Binding Sites
    Collagen Type I
    European Continental Ancestry Group
    Female
    Fractures, Bone
    Genetic Predisposition to Disease
    Humans
    Middle Aged
    Osteoporosis
    Polymorphism, Genetic
    Postmenopause
    Sp1 Transcription Factor
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    Citation
    Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis., 37 (6):1725-32 J. Int. Med. Res.
    Journal
    The Journal of international medical research
    URI
    http://hdl.handle.net/10147/200772
    PubMed ID
    20146870
    Abstract
    This study was designed to summarize quantitatively the evidence for a relationship between collagen type I alpha1 (COLIA1) Sp1 polymorphism and osteoporotic fracture risk in Caucasian post-menopausal women. This meta-analysis included 16 studies, which analysed 2294 patients with fractures and 10 285 controls. The combined results showed that there was a significant difference in genotype distribution (SS odds ratio [OR] 0.72; Ss OR 1.18; ss OR 1.97) between patients with fractures and controls. When stratifying by the fracture site, it was found that: (i) patients with vertebral fractures had a significantly higher frequency of the Ss genotype and a lower frequency of the SS genotype than controls; and (ii) patients with non-vertebral fractures had a significantly higher frequency of the ss genotype and a lower frequency of the SS genotype than controls. This meta-analysis suggests that the COLIA1 Sp1 polymorphism may be associated with osteoporotic fracture in Caucasian post-menopausal women.
    Item Type
    Article
    Language
    en
    ISSN
    0300-0605
    Collections
    Cork University Hospital

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