Apolipoprotein e genotype, plasma cholesterol, and cancer: a Mendelian randomization study.
Jukema, J Wouter
Katan, Martijn B
Blauw, Gerard J
Westendorp, Rudi G J
de Craen, Anton J M
AffiliationDepartment of Gerontology and Geriatrics, C-2-R Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, the Netherlands. email@example.com
Aged, 80 and over
Mendelian Randomization Analysis
Proportional Hazards Models
MetadataShow full item record
CitationApolipoprotein e genotype, plasma cholesterol, and cancer: a Mendelian randomization study. 2009, 170 (11):1415-21 Am. J. Epidemiol.
JournalAmerican journal of epidemiology
AbstractObservational studies have shown an association between low plasma cholesterol levels and increased risk of cancer, whereas most randomized clinical trials involving cholesterol-lowering medications have not shown this association. Between 1997 and 2002, the authors assessed the association between plasma cholesterol levels and cancer risk, free from confounding and reverse causality, in a Mendelian randomization study using apolipoprotein E (ApoE) genotype. ApoE genotype, plasma cholesterol levels, and cancer incidence and mortality were measured during a 3-year follow-up period among 2,913 participants in the Prospective Study of Pravastatin in the Elderly at Risk. Subjects within the lowest third of plasma cholesterol level at baseline had increased risks of cancer incidence (hazard ratio (HR) = 1.90, 95% confidence interval (CI): 1.34, 2.70) and cancer mortality (HR = 2.03, 95% CI: 1.23, 3.34) relative to subjects within the highest third of plasma cholesterol. However, carriers of the ApoE2 genotype (n = 332), who had 9% lower plasma cholesterol levels than carriers of the ApoE4 genotype (n = 635), did not have increased risk of cancer incidence (HR = 0.86, 95% CI: 0.50, 1.47) or cancer mortality (HR = 0.70, 95% CI: 0.30, 1.60) compared with ApoE4 carriers. These findings suggest that low cholesterol levels are not causally related to increased cancer risk.
- Relationship between plasma lipids and all-cause mortality in nondemented elderly.
- Authors: Schupf N, Costa R, Luchsinger J, Tang MX, Lee JH, Mayeux R
- Issue date: 2005 Feb
- Association of apolipoprotein E gene polymorphism with ischemic stroke involving large-vessel disease and its relation to serum lipid levels.
- Authors: Saidi S, Slamia LB, Ammou SB, Mahjoub T, Almawi WY
- Issue date: 2007 Jul-Aug
- The effect of apoE genotype and sex on ApoE plasma concentration is determined by dietary fat in healthy subjects.
- Authors: Moreno JA, Pérez-Jiménez F, Moreno-Luna R, Pérez-Martínez P, Fuentes-Jiménez F, Marín C, Portugal H, Lairon D, López-Miranda J
- Issue date: 2009 Jun
- Serum cholesterol, apolipoprotein E genotype and depressive symptoms in elderly European men: the FINE study.
- Authors: Giltay EJ, van Reedt Dortland AK, Nissinen A, Giampaoli S, van Veen T, Zitman FG, Bots S, Kromhout D
- Issue date: 2009 Jun
- A 12-week worksite health promotion program reduces cardiovascular risk factors in male workers with the apolipoprotein E2 and apolipoprotein E3 genotypes, but not in apolipoprotein E4 genotype.
- Authors: Cho SW, Kang JY, Park YK, Paek YM, Choi TI
- Issue date: 2009 Aug