Pravastatin and cognitive function in the elderly. Results of the PROSPER study.
Authors
Trompet, Stellavan Vliet, Peter
de Craen, Anton J M
Jolles, Jelle
Buckley, Brendan M
Murphy, Michael B
Ford, Ian
Macfarlane, Peter W
Sattar, Naveed
Packard, Chris J
Stott, David J
Shepherd, Jim
Bollen, Eduard L E M
Blauw, Gerard J
Jukema, J Wouter
Westendorp, Rudi G J
Affiliation
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. s.trompet@lumc.nlIssue Date
2010-01MeSH
AgedAging
Anticholesteremic Agents
Cognition
Cognition Disorders
Female
Follow-Up Studies
Humans
Male
Neuropsychological Tests
Nootropic Agents
Pravastatin
Prospective Studies
Time Factors
Treatment Outcome
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Pravastatin and cognitive function in the elderly. Results of the PROSPER study. 2010, 257 (1):85-90 J. Neurol.Journal
Journal of neurologyDOI
10.1007/s00415-009-5271-7PubMed ID
19653027Abstract
Observational studies have given conflicting results about the effect of statins in preventing dementia and cognitive decline. Moreover, observational studies are subject to prescription bias, making it hard to draw definite conclusions from them. Randomized controlled trials are therefore the preferred study design to investigate the association between statins and cognition. Here we present detailed cognitive outcomes from the randomized placebo-controlled PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Cognitive function was assessed repeatedly in all 5,804 PROSPER participants at six different time points during the study using four neuropsychological performance tests. After a mean follow-up period of 42 months, no difference in cognitive decline at any of the cognitive domains was found in subjects treated with pravastatin compared to placebo (all p > 0.05). Pravastatin treatment in old age did not affect cognitive decline during a 3 year follow-up period. Employing statin therapy in the elderly in an attempt to prevent cognitive decline therefore seems to be futile.Item Type
ArticleLanguage
enISSN
1432-1459ae974a485f413a2113503eed53cd6c53
10.1007/s00415-009-5271-7
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