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    Pravastatin and cognitive function in the elderly. Results of the PROSPER study.

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    Authors
    Trompet, Stella
    van Vliet, Peter
    de Craen, Anton J M
    Jolles, Jelle
    Buckley, Brendan M
    Murphy, Michael B
    Ford, Ian
    Macfarlane, Peter W
    Sattar, Naveed
    Packard, Chris J
    Stott, David J
    Shepherd, Jim
    Bollen, Eduard L E M
    Blauw, Gerard J
    Jukema, J Wouter
    Westendorp, Rudi G J
    Show allShow less
    Affiliation
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. s.trompet@lumc.nl
    Issue Date
    2010-01
    MeSH
    Aged
    Aging
    Anticholesteremic Agents
    Cognition
    Cognition Disorders
    Female
    Follow-Up Studies
    Humans
    Male
    Neuropsychological Tests
    Nootropic Agents
    Pravastatin
    Prospective Studies
    Time Factors
    Treatment Outcome
    Show allShow less
    
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    Citation
    Pravastatin and cognitive function in the elderly. Results of the PROSPER study. 2010, 257 (1):85-90 J. Neurol.
    Journal
    Journal of neurology
    URI
    http://hdl.handle.net/10147/200349
    DOI
    10.1007/s00415-009-5271-7
    PubMed ID
    19653027
    Abstract
    Observational studies have given conflicting results about the effect of statins in preventing dementia and cognitive decline. Moreover, observational studies are subject to prescription bias, making it hard to draw definite conclusions from them. Randomized controlled trials are therefore the preferred study design to investigate the association between statins and cognition. Here we present detailed cognitive outcomes from the randomized placebo-controlled PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Cognitive function was assessed repeatedly in all 5,804 PROSPER participants at six different time points during the study using four neuropsychological performance tests. After a mean follow-up period of 42 months, no difference in cognitive decline at any of the cognitive domains was found in subjects treated with pravastatin compared to placebo (all p > 0.05). Pravastatin treatment in old age did not affect cognitive decline during a 3 year follow-up period. Employing statin therapy in the elderly in an attempt to prevent cognitive decline therefore seems to be futile.
    Item Type
    Article
    Language
    en
    ISSN
    1432-1459
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00415-009-5271-7
    Scopus Count
    Collections
    Cork University Hospital

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