Pravastatin and cognitive function in the elderly. Results of the PROSPER study.
van Vliet, Peter
de Craen, Anton J M
Buckley, Brendan M
Murphy, Michael B
Macfarlane, Peter W
Packard, Chris J
Stott, David J
Bollen, Eduard L E M
Blauw, Gerard J
Jukema, J Wouter
Westendorp, Rudi G J
AffiliationDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. email@example.com
MetadataShow full item record
CitationPravastatin and cognitive function in the elderly. Results of the PROSPER study. 2010, 257 (1):85-90 J. Neurol.
JournalJournal of neurology
AbstractObservational studies have given conflicting results about the effect of statins in preventing dementia and cognitive decline. Moreover, observational studies are subject to prescription bias, making it hard to draw definite conclusions from them. Randomized controlled trials are therefore the preferred study design to investigate the association between statins and cognition. Here we present detailed cognitive outcomes from the randomized placebo-controlled PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Cognitive function was assessed repeatedly in all 5,804 PROSPER participants at six different time points during the study using four neuropsychological performance tests. After a mean follow-up period of 42 months, no difference in cognitive decline at any of the cognitive domains was found in subjects treated with pravastatin compared to placebo (all p > 0.05). Pravastatin treatment in old age did not affect cognitive decline during a 3 year follow-up period. Employing statin therapy in the elderly in an attempt to prevent cognitive decline therefore seems to be futile.
- Statins for the prevention of dementia.
- Authors: McGuinness B, Craig D, Bullock R, Passmore P
- Issue date: 2009 Apr 15
- Statins, risk of dementia, and cognitive function: secondary analysis of the ginkgo evaluation of memory study.
- Authors: Bettermann K, Arnold AM, Williamson J, Rapp S, Sink K, Toole JF, Carlson MC, Yasar S, Dekosky S, Burke GL
- Issue date: 2012 Aug
- Association between apolipoprotein E4 and cognitive decline in elderly adults.
- Authors: Packard CJ, Westendorp RG, Stott DJ, Caslake MJ, Murray HM, Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Cobbe SM, Ford I, Gaw A, Hyland M, Jukema JW, Kamper AM, Macfarlane PW, Jolles J, Perry IJ, Sweeney BJ, Twomey C, Prospective Study of Pravastatin in the Elderly at Risk Group.
- Issue date: 2007 Nov
- Statins and cognitive function in the elderly: the Cardiovascular Health Study.
- Authors: Bernick C, Katz R, Smith NL, Rapp S, Bhadelia R, Carlson M, Kuller L, Cardiovascular Health Study Collaborative Research Group.
- Issue date: 2005 Nov 8
- Testing cognitive function in elderly populations: the PROSPER study. PROspective Study of Pravastatin in the Elderly at Risk.
- Authors: Houx PJ, Shepherd J, Blauw GJ, Murphy MB, Ford I, Bollen EL, Buckley B, Stott DJ, Jukema W, Hyland M, Gaw A, Norrie J, Kamper AM, Perry IJ, MacFarlane PW, Meinders AE, Sweeney BJ, Packard CJ, Twomey C, Cobbe SM, Westendorp RG
- Issue date: 2002 Oct