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    A molecular analysis of fecal and mucosal bacterial communities in irritable bowel syndrome.

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    Authors
    Codling, Caroline
    O'Mahony, Liam
    Shanahan, Fergus
    Quigley, Eamonn M M
    Marchesi, Julian R
    Affiliation
    Department of Medicine, Alimentary Pharmabiotic Centre, Cork University Hospital, Cork, Ireland.
    Issue Date
    2010-02
    MeSH
    Adult
    Aged
    Bacteria
    Biopsy
    Colon
    DNA, Bacterial
    Feces
    Female
    Humans
    Intestinal Mucosa
    Irritable Bowel Syndrome
    Metagenome
    Middle Aged
    Polymerase Chain Reaction
    Young Adult
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    Citation
    A molecular analysis of fecal and mucosal bacterial communities in irritable bowel syndrome. 2010, 55 (2):392-7 Dig. Dis. Sci.
    Journal
    Digestive diseases and sciences
    URI
    http://hdl.handle.net/10147/200335
    DOI
    10.1007/s10620-009-0934-x
    PubMed ID
    19693670
    Abstract
    The objectives of this study were, firstly, to determine the diversity of the host's gut microbiota in irritable bowel syndrome (IBS) using a culture-independent method (DGGE of the 16S rRNA gene) and, secondly, to examine mucosal biopsies of IBS patients and compare them to their own fecal microbiota.
    The diversity of the dominant microbiota in the fecal material of IBS patients was compared to a healthy control group. In addition, we compared the mucosal and fecal microbiota of IBS patients.
    Statistical analysis of the mean similarity data for these groups indicated a significant difference (P < 0.001) between IBS (n = 47) and healthy controls (n = 33) with significantly more variation in the gut microbiota of healthy volunteers than that of IBS patients. The average intra-individual similarity between the mucosa and luminal microbiota was 84%, which indicates that different communities were present at the two sites. This difference, however, is similar to that previously described between these two niches in control subjects. The average inter-individual similarity of the bacterial communities on the mucosa and in the lumen of IBS was not significantly different (P > 0.05).
    IBS impacts equally on both bacterial communities in the IBS host and a significant difference in the gut microbiota exists between fecal samples from IBS patients and healthy controls. The reason for this difference is unclear and various possible explanations are available, but much more work is required to determine the underlying reason for this observation.
    Item Type
    Article
    Language
    en
    ISSN
    1573-2568
    ae974a485f413a2113503eed53cd6c53
    10.1007/s10620-009-0934-x
    Scopus Count
    Collections
    Cork University Hospital

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