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dc.contributor.authorBurke, Siun M
dc.contributor.authorShorten, George D
dc.date.accessioned2012-01-05T14:16:54Z
dc.date.available2012-01-05T14:16:54Z
dc.date.issued2010-04-01
dc.identifier.citationPerioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy. 2010, 110 (4):1180-5 Anesth. Analg.en
dc.identifier.issn1526-7598
dc.identifier.pmid20103545
dc.identifier.doi10.1213/ANE.0b013e3181cf949a
dc.identifier.urihttp://hdl.handle.net/10147/200311
dc.descriptionBACKGROUND: Patient outcome after lumbar discectomy for radicular low back pain is variable and the benefit is inconsistent. Many patients continue to experience pain 3 months after surgery. Pregabalin, a membrane stabilizer, may decrease perioperative central sensitization and subsequent persistent pain. METHODS: Forty patients undergoing lumbar discectomy were randomly allocated to receive either pregabalin (300 mg at 90 minutes preoperatively and 150 mg at 12 and 24 hours postoperatively) or placebo at corresponding times in a double-blinded manner. Our primary outcome was the change in the present pain intensity (PPI) (visual analog scale [VAS], 0-100 mm [PPI-VAS, McGill Pain Questionnaire]) from preoperatively to 3 months postoperatively. RESULTS: The decrease in PPI-VAS score at 3 months was greater in patients who received pregabalin (37.6 +/- 19.6 mm) (mean +/- sd) than those who received placebo (25.3 +/- 21.9 mm) (P = 0.08). The Roland Morris disability score at 3 months was less in patients who received pregabalin (2.7 +/- 2.4) than in those who received placebo (5.6 +/- 4.8) (P = 0.032). Pregabalin administration was associated with greater pain tolerance thresholds in both lower limbs compared with placebo at 24 hours postoperatively. CONCLUSION: Perioperative pregabalin administration is associated with less pain intensity and improved functional outcomes 3 months after lumbar discectomy.en
dc.description.abstractPatient outcome after lumbar discectomy for radicular low back pain is variable and the benefit is inconsistent. Many patients continue to experience pain 3 months after surgery. Pregabalin, a membrane stabilizer, may decrease perioperative central sensitization and subsequent persistent pain.
dc.description.abstractForty patients undergoing lumbar discectomy were randomly allocated to receive either pregabalin (300 mg at 90 minutes preoperatively and 150 mg at 12 and 24 hours postoperatively) or placebo at corresponding times in a double-blinded manner. Our primary outcome was the change in the present pain intensity (PPI) (visual analog scale [VAS], 0-100 mm [PPI-VAS, McGill Pain Questionnaire]) from preoperatively to 3 months postoperatively.
dc.description.abstractThe decrease in PPI-VAS score at 3 months was greater in patients who received pregabalin (37.6 +/- 19.6 mm) (mean +/- sd) than those who received placebo (25.3 +/- 21.9 mm) (P = 0.08). The Roland Morris disability score at 3 months was less in patients who received pregabalin (2.7 +/- 2.4) than in those who received placebo (5.6 +/- 4.8) (P = 0.032). Pregabalin administration was associated with greater pain tolerance thresholds in both lower limbs compared with placebo at 24 hours postoperatively.
dc.description.abstractPerioperative pregabalin administration is associated with less pain intensity and improved functional outcomes 3 months after lumbar discectomy.
dc.language.isoenen
dc.relation.urlhttp://www.anesthesia-analgesia.org/content/110/4/1180.full.pdf+htmlen
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAnalgesics
dc.subject.meshAnesthesia
dc.subject.meshDNA
dc.subject.meshDiskectomy
dc.subject.meshDouble-Blind Method
dc.subject.meshElectric Stimulation
dc.subject.meshFemale
dc.subject.meshHemodynamics
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPain Measurement
dc.subject.meshPain Threshold
dc.subject.meshPain, Postoperative
dc.subject.meshReceptors, Opioid, mu
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction
dc.subject.meshTreatment Outcome
dc.subject.meshYoung Adult
dc.subject.meshgamma-Aminobutyric Acid
dc.titlePerioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Anaesthesia and Intensive Care Medicine, Cork University Hospital, Wilton, Cork, Ireland. siunburke@hotmail.comen
dc.identifier.journalAnesthesia and analgesiaen
dc.description.provinceMunster
html.description.abstractPatient outcome after lumbar discectomy for radicular low back pain is variable and the benefit is inconsistent. Many patients continue to experience pain 3 months after surgery. Pregabalin, a membrane stabilizer, may decrease perioperative central sensitization and subsequent persistent pain.
html.description.abstractForty patients undergoing lumbar discectomy were randomly allocated to receive either pregabalin (300 mg at 90 minutes preoperatively and 150 mg at 12 and 24 hours postoperatively) or placebo at corresponding times in a double-blinded manner. Our primary outcome was the change in the present pain intensity (PPI) (visual analog scale [VAS], 0-100 mm [PPI-VAS, McGill Pain Questionnaire]) from preoperatively to 3 months postoperatively.
html.description.abstractThe decrease in PPI-VAS score at 3 months was greater in patients who received pregabalin (37.6 +/- 19.6 mm) (mean +/- sd) than those who received placebo (25.3 +/- 21.9 mm) (P = 0.08). The Roland Morris disability score at 3 months was less in patients who received pregabalin (2.7 +/- 2.4) than in those who received placebo (5.6 +/- 4.8) (P = 0.032). Pregabalin administration was associated with greater pain tolerance thresholds in both lower limbs compared with placebo at 24 hours postoperatively.
html.description.abstractPerioperative pregabalin administration is associated with less pain intensity and improved functional outcomes 3 months after lumbar discectomy.


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