Perioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy.
Affiliation
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, Wilton, Cork, Ireland. siunburke@hotmail.comIssue Date
2010-04-01MeSH
AdolescentAdult
Analgesics
Anesthesia
DNA
Diskectomy
Double-Blind Method
Electric Stimulation
Female
Hemodynamics
Humans
Male
Middle Aged
Pain Measurement
Pain Threshold
Pain, Postoperative
Receptors, Opioid, mu
Reverse Transcriptase Polymerase Chain Reaction
Treatment Outcome
Young Adult
gamma-Aminobutyric Acid
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Perioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy. 2010, 110 (4):1180-5 Anesth. Analg.Journal
Anesthesia and analgesiaDOI
10.1213/ANE.0b013e3181cf949aPubMed ID
20103545Additional Links
http://www.anesthesia-analgesia.org/content/110/4/1180.full.pdf+htmlAbstract
Patient outcome after lumbar discectomy for radicular low back pain is variable and the benefit is inconsistent. Many patients continue to experience pain 3 months after surgery. Pregabalin, a membrane stabilizer, may decrease perioperative central sensitization and subsequent persistent pain.Forty patients undergoing lumbar discectomy were randomly allocated to receive either pregabalin (300 mg at 90 minutes preoperatively and 150 mg at 12 and 24 hours postoperatively) or placebo at corresponding times in a double-blinded manner. Our primary outcome was the change in the present pain intensity (PPI) (visual analog scale [VAS], 0-100 mm [PPI-VAS, McGill Pain Questionnaire]) from preoperatively to 3 months postoperatively.
The decrease in PPI-VAS score at 3 months was greater in patients who received pregabalin (37.6 +/- 19.6 mm) (mean +/- sd) than those who received placebo (25.3 +/- 21.9 mm) (P = 0.08). The Roland Morris disability score at 3 months was less in patients who received pregabalin (2.7 +/- 2.4) than in those who received placebo (5.6 +/- 4.8) (P = 0.032). Pregabalin administration was associated with greater pain tolerance thresholds in both lower limbs compared with placebo at 24 hours postoperatively.
Perioperative pregabalin administration is associated with less pain intensity and improved functional outcomes 3 months after lumbar discectomy.
Item Type
ArticleLanguage
enISSN
1526-7598ae974a485f413a2113503eed53cd6c53
10.1213/ANE.0b013e3181cf949a
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