• Login
    View Item 
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    5118
    UlsterS
    5118
    Connacht
    1710
    Munster
    58
    Leinster
    467

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Perioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Burke, Siun M
    Shorten, George D
    Affiliation
    Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, Wilton, Cork, Ireland. siunburke@hotmail.com
    Issue Date
    2010-04-01
    MeSH
    Adolescent
    Adult
    Analgesics
    Anesthesia
    DNA
    Diskectomy
    Double-Blind Method
    Electric Stimulation
    Female
    Hemodynamics
    Humans
    Male
    Middle Aged
    Pain Measurement
    Pain Threshold
    Pain, Postoperative
    Receptors, Opioid, mu
    Reverse Transcriptase Polymerase Chain Reaction
    Treatment Outcome
    Young Adult
    gamma-Aminobutyric Acid
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Perioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy. 2010, 110 (4):1180-5 Anesth. Analg.
    Journal
    Anesthesia and analgesia
    URI
    http://hdl.handle.net/10147/200311
    DOI
    10.1213/ANE.0b013e3181cf949a
    PubMed ID
    20103545
    Additional Links
    http://www.anesthesia-analgesia.org/content/110/4/1180.full.pdf+html
    Abstract
    Patient outcome after lumbar discectomy for radicular low back pain is variable and the benefit is inconsistent. Many patients continue to experience pain 3 months after surgery. Pregabalin, a membrane stabilizer, may decrease perioperative central sensitization and subsequent persistent pain.
    Forty patients undergoing lumbar discectomy were randomly allocated to receive either pregabalin (300 mg at 90 minutes preoperatively and 150 mg at 12 and 24 hours postoperatively) or placebo at corresponding times in a double-blinded manner. Our primary outcome was the change in the present pain intensity (PPI) (visual analog scale [VAS], 0-100 mm [PPI-VAS, McGill Pain Questionnaire]) from preoperatively to 3 months postoperatively.
    The decrease in PPI-VAS score at 3 months was greater in patients who received pregabalin (37.6 +/- 19.6 mm) (mean +/- sd) than those who received placebo (25.3 +/- 21.9 mm) (P = 0.08). The Roland Morris disability score at 3 months was less in patients who received pregabalin (2.7 +/- 2.4) than in those who received placebo (5.6 +/- 4.8) (P = 0.032). Pregabalin administration was associated with greater pain tolerance thresholds in both lower limbs compared with placebo at 24 hours postoperatively.
    Perioperative pregabalin administration is associated with less pain intensity and improved functional outcomes 3 months after lumbar discectomy.
    Item Type
    Article
    Language
    en
    ISSN
    1526-7598
    ae974a485f413a2113503eed53cd6c53
    10.1213/ANE.0b013e3181cf949a
    Scopus Count
    Collections
    Cork University Hospital

    entitlement

    Related articles

    • Effect of a single dose of pregabalin on post-operative pain and pre-operative anxiety in patients undergoing discectomy.
    • Authors: Spreng UJ, Dahl V, Raeder J
    • Issue date: 2011 May
    • Postoperative pain and long-term functional outcome after administration of gabapentin and pregabalin in patients undergoing spinal surgery.
    • Authors: Khurana G, Jindal P, Sharma JP, Bansal KK
    • Issue date: 2014 Mar 15
    • Perioperative administration of gabapentin 1,200 mg day-1 and pregabalin 300 mg day-1 for pain following lumbar laminectomy and discectomy: a randomised, double-blinded, placebo-controlled study.
    • Authors: Ozgencil E, Yalcin S, Tuna H, Yorukoglu D, Kecik Y
    • Issue date: 2011 Dec
    • Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective, randomized, controlled trial.
    • Authors: Buvanendran A, Kroin JS, Della Valle CJ, Kari M, Moric M, Tuman KJ
    • Issue date: 2010 Jan 1
    • Efficacy of pregabalin for peripheral neuropathic pain: results of an 8-week, flexible-dose, double-blind, placebo-controlled study conducted in China.
    • Authors: Guan Y, Ding X, Cheng Y, Fan D, Tan L, Wang Y, Zhao Z, Hong Z, Zhou D, Pan X, Chen S, Martin A, Tang H, Cui L
    • Issue date: 2011 Feb
    Health Library Ireland | Health Service Executive | Jervis House, Jervis Street | Republic of Ireland | Eircode: D01 W596
    lenus@hse.ie | Tel: +353-1-7786275
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.