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    The use of abatacept in debilitating cavitating lung disease associated with rheumatoid arthritis, bronchocentric granulomatosis and aspergillosis.

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    Authors
    Neff, K
    Stack, J
    Harney, S
    Henry, M
    Affiliation
    Department of Respiratory Medicine, Cork University Hospital, Cork, Ireland. karljneff@gmail.com
    Issue Date
    2010-06
    MeSH
    Adult
    Antirheumatic Agents
    Arthritis, Rheumatoid
    Female
    Granuloma
    Humans
    Immunoconjugates
    Lung Diseases
    Opportunistic Infections
    Pulmonary Aspergillosis
    
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    Citation
    The use of abatacept in debilitating cavitating lung disease associated with rheumatoid arthritis, bronchocentric granulomatosis and aspergillosis. 2010, 65 (6):545-6 Thorax
    Journal
    Thorax
    URI
    http://hdl.handle.net/10147/200309
    DOI
    10.1136/thx.2009.128710
    PubMed ID
    20522855
    Abstract
    A case of debilitating cavitating lung disease associated with rheumatoid arthritis and bronchocentric granulomatosis, which failed to respond to conventional medical or surgical treatment, is described. The patient was treated over 10 years with steroids, antimicrobial agents, disease-modifying antirheumatoid drugs and surgery. Lung function continued to decline and the patient presented for admission with recurrent pneumonia. Abatacept was initiated to modify the underlying immunopathology. Following 12 months of treatment with abatacept the patient has demonstrable improvement in lung function and lung anatomy, and has not presented to hospital with pneumonia. She has tolerated the treatment without complication. The use of abatacept has stabilised the lung disease in this case in the medium term and prevented readmission to hospital. These results suggest a larger role for abatacept in those with such disease in the future and may warrant further investigation.
    Item Type
    Article
    Language
    en
    ISSN
    1468-3296
    ae974a485f413a2113503eed53cd6c53
    10.1136/thx.2009.128710
    Scopus Count
    Collections
    Cork University Hospital

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