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    Bacteria, genetics and irritable bowel syndrome.

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    Authors
    Craig, Orla F
    Quigley, Eamonn M M
    Affiliation
    University College Cork, Cork, Ireland.
    Issue Date
    2010-06
    
    Metadata
    Show full item record
    Citation
    Bacteria, genetics and irritable bowel syndrome. 2010, 4 (3):271-6 Expert Rev Gastroenterol Hepatol
    Journal
    Expert review of gastroenterology & hepatology
    URI
    http://hdl.handle.net/10147/200293
    DOI
    10.1586/egh.10.31
    PubMed ID
    20528114
    Abstract
    EVALUATION OF: Villani AC, Lemire M, Thabane M et al. Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis. Gastroenterology 138, 1502-1513 (2010). While the pathogenesis of irritable bowel syndrome (IBS) remains to be fully defined, two clinical observations - the occurrence, de novo, of IBS following bacterial gastroenteritis and the history, commonly obtained from IBS patients, of other instances of the syndrome within their families - have instigated investigations, in IBS, of the potential roles, on the one hand, of the gut microbiota and the host response and, on the other hand, of genetic factors. The study reviewed here relates to both of these factors by studying genetic predisposition to postinfective IBS in a large population of individuals who were exposed to a multimicrobial enteric infection, which resulted in a severe outbreak of gastroenteritis and was followed by the development of IBS in over a third. In this detailed study, the investigators identified a number of genes that were linked significantly to the development of postinfectious-IBS in the Toll-like receptor 9, IL-6 and cadherin 1 regions. These genes play important roles in bacterial recognition, the inflammatory response and epithelial integrity, respectively, and provide considerable support for the hypothesis that links IBS onset to disturbances in the microbiota and the host response.
    Item Type
    Article
    Language
    en
    ISSN
    1747-4132
    ae974a485f413a2113503eed53cd6c53
    10.1586/egh.10.31
    Scopus Count
    Collections
    Cork University Hospital

    entitlement

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