Macrolide antibiotics and the airway: antibiotic or non-antibiotic effects?
| dc.contributor.author | Murphy, D M | |
| dc.contributor.author | Forrest, I A | |
| dc.contributor.author | Curran, D | |
| dc.contributor.author | Ward, C | |
| dc.date.accessioned | 2012-01-05T14:41:32Z | |
| dc.date.available | 2012-01-05T14:41:32Z | |
| dc.date.issued | 2010-03 | |
| dc.identifier.citation | Macrolide antibiotics and the airway: antibiotic or non-antibiotic effects? 2010, 19 (3):401-14 Expert Opin Investig Drugs | en |
| dc.identifier.issn | 1744-7658 | |
| dc.identifier.pmid | 20151856 | |
| dc.identifier.doi | 10.1517/13543781003636480 | |
| dc.identifier.uri | http://hdl.handle.net/10147/200279 | |
| dc.description | Different crystallins (alpha, beta H, beta L and LMW) were isolated from bovine lenses. Lyophilized samples of single components (homoaggregates) and those of mixtures (heteroaggregates) were exposed to HCI vapor in a high vacuum vapor sorption apparatus. Lyophilized 5-microns sections of bovine lens were similarly exposed to HCI vapors. Sorption and desorption isotherms were obtained at two temperatures on all samples. Fourier transform infrared (FT IR) spectroscopy was conducted on solid samples of crystallin with and without irreversibly sorbed HCI gas. From the IR spectra the nature of interaction between HCI and protein were ascertained. From the sorption parameters, mainly from the irreversibly sorbed HCI, the accessibilities of homo and hetero aggregates were calculated. The accessibilities provided information on the preferential interactions among crystallins. One of the main conclusions derived from this and also from previous ammonia sorption studies is that the supramolecular organization in the lens fibers is not governed solely by the thermodynamically preferential interactions of crystallins, but also by other possibly cytoskeletal organizations of crystallins. | en |
| dc.description.abstract | The macrolides are a class of antibiotics widely prescribed in infectious disease. More recently, there has been considerable interest in potential indications for these agents, in addition to their simple antibacterial indications, in a number of lung pathophysiologies. | |
| dc.description.abstract | Demonstrated clinical efficacy of macrolides in diseases such as diffuse panbronchiolitis was difficult to ascribe to a direct antimicrobial action. More recently, positive experiences in dealing with post-transplant bronchiolitis obliterans syndrome suggests that other chronic lung diseases may benefit from macrolide therapy. This is important, as the treatment options for such diseases are often very limited. In this review, potential antibiotic and non-antibiotic beneficial actions of macrolide therapy are discussed and conclusions drawn from a limited but growing literature. | |
| dc.description.abstract | The reader will gain an overview of lung diseases that may benefit from macrolides, and a consideration of the possible mechanisms underlying such benefit. | |
| dc.description.abstract | The key message from our review is that this class of agents may prove to be a useful therapeutic option for a range of respiratory diseases, but that further trials and mechanistic studies are required to clarify their role. | |
| dc.language.iso | en | en |
| dc.subject.mesh | Animals | |
| dc.subject.mesh | Anti-Bacterial Agents | |
| dc.subject.mesh | Bronchiolitis Obliterans | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Lung Diseases | |
| dc.subject.mesh | Lung Transplantation | |
| dc.subject.mesh | Macrolides | |
| dc.title | Macrolide antibiotics and the airway: antibiotic or non-antibiotic effects? | en |
| dc.type | Article | en |
| dc.contributor.department | Cork University Hospital, The Department of Respiratory Medicine, Wilton, Cork, Ireland. desmond.murphy@hse.ie | en |
| dc.identifier.journal | Expert opinion on investigational drugs | en |
| dc.description.province | Munster | |
| html.description.abstract | The macrolides are a class of antibiotics widely prescribed in infectious disease. More recently, there has been considerable interest in potential indications for these agents, in addition to their simple antibacterial indications, in a number of lung pathophysiologies. | |
| html.description.abstract | Demonstrated clinical efficacy of macrolides in diseases such as diffuse panbronchiolitis was difficult to ascribe to a direct antimicrobial action. More recently, positive experiences in dealing with post-transplant bronchiolitis obliterans syndrome suggests that other chronic lung diseases may benefit from macrolide therapy. This is important, as the treatment options for such diseases are often very limited. In this review, potential antibiotic and non-antibiotic beneficial actions of macrolide therapy are discussed and conclusions drawn from a limited but growing literature. | |
| html.description.abstract | The reader will gain an overview of lung diseases that may benefit from macrolides, and a consideration of the possible mechanisms underlying such benefit. | |
| html.description.abstract | The key message from our review is that this class of agents may prove to be a useful therapeutic option for a range of respiratory diseases, but that further trials and mechanistic studies are required to clarify their role. |