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    Macrolide antibiotics and the airway: antibiotic or non-antibiotic effects?

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    Authors
    Murphy, D M
    Forrest, I A
    Curran, D
    Ward, C
    Affiliation
    Cork University Hospital, The Department of Respiratory Medicine, Wilton, Cork, Ireland. desmond.murphy@hse.ie
    Issue Date
    2010-03
    MeSH
    Animals
    Anti-Bacterial Agents
    Bronchiolitis Obliterans
    Humans
    Lung Diseases
    Lung Transplantation
    Macrolides
    
    Metadata
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    Citation
    Macrolide antibiotics and the airway: antibiotic or non-antibiotic effects? 2010, 19 (3):401-14 Expert Opin Investig Drugs
    Journal
    Expert opinion on investigational drugs
    URI
    http://hdl.handle.net/10147/200279
    DOI
    10.1517/13543781003636480
    PubMed ID
    20151856
    Abstract
    The macrolides are a class of antibiotics widely prescribed in infectious disease. More recently, there has been considerable interest in potential indications for these agents, in addition to their simple antibacterial indications, in a number of lung pathophysiologies.
    Demonstrated clinical efficacy of macrolides in diseases such as diffuse panbronchiolitis was difficult to ascribe to a direct antimicrobial action. More recently, positive experiences in dealing with post-transplant bronchiolitis obliterans syndrome suggests that other chronic lung diseases may benefit from macrolide therapy. This is important, as the treatment options for such diseases are often very limited. In this review, potential antibiotic and non-antibiotic beneficial actions of macrolide therapy are discussed and conclusions drawn from a limited but growing literature.
    The reader will gain an overview of lung diseases that may benefit from macrolides, and a consideration of the possible mechanisms underlying such benefit.
    The key message from our review is that this class of agents may prove to be a useful therapeutic option for a range of respiratory diseases, but that further trials and mechanistic studies are required to clarify their role.
    Item Type
    Article
    Language
    en
    ISSN
    1744-7658
    ae974a485f413a2113503eed53cd6c53
    10.1517/13543781003636480
    Scopus Count
    Collections
    Cork University Hospital

    entitlement

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