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dc.contributor.authorMollaghan, A M
dc.contributor.authorLucey, B
dc.contributor.authorCoffey, A
dc.contributor.authorCotter, L
dc.date.accessioned2012-01-05T14:06:40Z
dc.date.available2012-01-05T14:06:40Z
dc.date.issued2010-05
dc.identifier.citationEmergence of MRSA clone ST22 in healthy young adults in the community in the absence of risk factors. 2010, 138 (5):673-6 Epidemiol. Infect.en
dc.identifier.issn1469-4409
dc.identifier.pmid20144250
dc.identifier.doi10.1017/S0950268810000191
dc.identifier.urihttp://hdl.handle.net/10147/200273
dc.descriptionOne thousand adults aged between 18 and 35 years were investigated for nasal colonization with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Each volunteer completed a questionnaire to assess the presence or absence of risk factors for hospital-acquired MRSA (HA-MRSA) carriage. All MRSA isolated were characterized by microbiological and molecular methods. A S. aureus carriage rate of 22% and a MRSA carriage rate of 0.7% were observed. Analysis of the questionnaires revealed 121 individuals with HA-MRSA risk factors. Subsequently two MRSA infections with associated risk factors were excluded from calculation of the true carriage rate and an adjusted rate of 0.57% (5/879) was established. All seven MRSA isolates expressed the genotypic profile ST22-MRSA-IV, were PVL negative, agr type 1, and differed only by their antimicrobial susceptibility patterns. ST22-MRSA-IV (EMRSA-15) has shown worldwide spread in the hospital setting but has not been previously documented in isolation in the community.en
dc.description.abstractOne thousand adults aged between 18 and 35 years were investigated for nasal colonization with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Each volunteer completed a questionnaire to assess the presence or absence of risk factors for hospital-acquired MRSA (HA-MRSA) carriage. All MRSA isolated were characterized by microbiological and molecular methods. A S. aureus carriage rate of 22% and a MRSA carriage rate of 0.7% were observed. Analysis of the questionnaires revealed 121 individuals with HA-MRSA risk factors. Subsequently two MRSA infections with associated risk factors were excluded from calculation of the true carriage rate and an adjusted rate of 0.57% (5/879) was established. All seven MRSA isolates expressed the genotypic profile ST22-MRSA-IV, were PVL negative, agr type 1, and differed only by their antimicrobial susceptibility patterns. ST22-MRSA-IV (EMRSA-15) has shown worldwide spread in the hospital setting but has not been previously documented in isolation in the community.
dc.language.isoenen
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshBacterial Proteins
dc.subject.meshBacterial Toxins
dc.subject.meshBacterial Typing Techniques
dc.subject.meshCarrier State
dc.subject.meshCommunity-Acquired Infections
dc.subject.meshDNA Fingerprinting
dc.subject.meshDNA, Bacterial
dc.subject.meshExotoxins
dc.subject.meshFemale
dc.subject.meshGenotype
dc.subject.meshHuman Experimentation
dc.subject.meshHumans
dc.subject.meshLeukocidins
dc.subject.meshMale
dc.subject.meshMethicillin-Resistant Staphylococcus aureus
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshNose
dc.subject.meshPrevalence
dc.subject.meshQuestionnaires
dc.subject.meshRisk Factors
dc.subject.meshStaphylococcal Infections
dc.subject.meshTrans-Activators
dc.subject.meshVirulence Factors
dc.subject.meshYoung Adult
dc.titleEmergence of MRSA clone ST22 in healthy young adults in the community in the absence of risk factors.en
dc.typeArticleen
dc.contributor.departmentDepartment of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork, Ireland.en
dc.identifier.journalEpidemiology and infectionen
dc.description.provinceMunster
html.description.abstractOne thousand adults aged between 18 and 35 years were investigated for nasal colonization with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Each volunteer completed a questionnaire to assess the presence or absence of risk factors for hospital-acquired MRSA (HA-MRSA) carriage. All MRSA isolated were characterized by microbiological and molecular methods. A S. aureus carriage rate of 22% and a MRSA carriage rate of 0.7% were observed. Analysis of the questionnaires revealed 121 individuals with HA-MRSA risk factors. Subsequently two MRSA infections with associated risk factors were excluded from calculation of the true carriage rate and an adjusted rate of 0.57% (5/879) was established. All seven MRSA isolates expressed the genotypic profile ST22-MRSA-IV, were PVL negative, agr type 1, and differed only by their antimicrobial susceptibility patterns. ST22-MRSA-IV (EMRSA-15) has shown worldwide spread in the hospital setting but has not been previously documented in isolation in the community.


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