Emergence of MRSA clone ST22 in healthy young adults in the community in the absence of risk factors.
Affiliation
Department of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork, Ireland.Issue Date
2010-05MeSH
AdolescentAdult
Bacterial Proteins
Bacterial Toxins
Bacterial Typing Techniques
Carrier State
Community-Acquired Infections
DNA Fingerprinting
DNA, Bacterial
Exotoxins
Female
Genotype
Human Experimentation
Humans
Leukocidins
Male
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Nose
Prevalence
Questionnaires
Risk Factors
Staphylococcal Infections
Trans-Activators
Virulence Factors
Young Adult
Metadata
Show full item recordCitation
Emergence of MRSA clone ST22 in healthy young adults in the community in the absence of risk factors. 2010, 138 (5):673-6 Epidemiol. Infect.Journal
Epidemiology and infectionDOI
10.1017/S0950268810000191PubMed ID
20144250Abstract
One thousand adults aged between 18 and 35 years were investigated for nasal colonization with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Each volunteer completed a questionnaire to assess the presence or absence of risk factors for hospital-acquired MRSA (HA-MRSA) carriage. All MRSA isolated were characterized by microbiological and molecular methods. A S. aureus carriage rate of 22% and a MRSA carriage rate of 0.7% were observed. Analysis of the questionnaires revealed 121 individuals with HA-MRSA risk factors. Subsequently two MRSA infections with associated risk factors were excluded from calculation of the true carriage rate and an adjusted rate of 0.57% (5/879) was established. All seven MRSA isolates expressed the genotypic profile ST22-MRSA-IV, were PVL negative, agr type 1, and differed only by their antimicrobial susceptibility patterns. ST22-MRSA-IV (EMRSA-15) has shown worldwide spread in the hospital setting but has not been previously documented in isolation in the community.Item Type
ArticleLanguage
enISSN
1469-4409ae974a485f413a2113503eed53cd6c53
10.1017/S0950268810000191
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