Multiple sclerosis exceptionally presenting as parkinsonism responds to intravenous methylprednisolone.
AffiliationDepartment of Neurology, Mercy University Hospital, Grenville Place, Cork, Ireland. email@example.com <firstname.lastname@example.org>
Magnetic Resonance Imaging
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CitationMultiple sclerosis exceptionally presenting as parkinsonism responds to intravenous methylprednisolone. 2010, 17 (5):654-5 J Clin Neurosci
JournalJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
AbstractParkinsonism due to multiple sclerosis (MS) is rare. In previously reported patients with MS-induced parkinsonism, MS manifested first, followed a typical clinical course, and parkinsonism developed later in the course of the illness. We report a 52-year-old male presenting with parkinsonism as the initial manifestation of MS, in whom a subsequent MS relapse consisted of marked deterioration in parkinsonism, a clinical pattern not previously described in MS. A brain MRI demonstrated involvement of the substantia nigra and basal ganglia. This patient illustrates that the clinical presentation and progression of MS may rarely be characterised by predominating parkinsonian features which are reversible by treatment with intravenous methylprednisolone and interferon beta1a.