Multiple sclerosis exceptionally presenting as parkinsonism responds to intravenous methylprednisolone.
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Affiliation
Department of Neurology, Mercy University Hospital, Grenville Place, Cork, Ireland. shivsaidha@physicians.ie <shivsaidha@physicians.ie>Issue Date
2010-05MeSH
Disease ProgressionGlucocorticoids
Humans
Magnetic Resonance Imaging
Male
Methylprednisolone
Middle Aged
Multiple Sclerosis
Parkinsonian Disorders
Treatment Outcome
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Multiple sclerosis exceptionally presenting as parkinsonism responds to intravenous methylprednisolone. 2010, 17 (5):654-5 J Clin NeurosciJournal
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaDOI
10.1016/j.jocn.2009.09.026PubMed ID
20219377Abstract
Parkinsonism due to multiple sclerosis (MS) is rare. In previously reported patients with MS-induced parkinsonism, MS manifested first, followed a typical clinical course, and parkinsonism developed later in the course of the illness. We report a 52-year-old male presenting with parkinsonism as the initial manifestation of MS, in whom a subsequent MS relapse consisted of marked deterioration in parkinsonism, a clinical pattern not previously described in MS. A brain MRI demonstrated involvement of the substantia nigra and basal ganglia. This patient illustrates that the clinical presentation and progression of MS may rarely be characterised by predominating parkinsonian features which are reversible by treatment with intravenous methylprednisolone and interferon beta1a.Item Type
ArticleLanguage
enISSN
1532-2653ae974a485f413a2113503eed53cd6c53
10.1016/j.jocn.2009.09.026