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    Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers.

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    Authors
    Jansen, Michael
    Yip, Stephen
    Louis, David N
    Affiliation
    Pathology Service, Massachusetts General Hospital, Boston, MA 02114, USA.
    Issue Date
    2010-07
    MeSH
    Brain Neoplasms
    Glioma
    Humans
    Pathology, Molecular
    Tumor Markers, Biological
    
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    Citation
    Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers. 2010, 9 (7):717-26 Lancet Neurol
    Publisher
    Elsevier
    Journal
    Lancet neurology
    URI
    http://hdl.handle.net/10147/200266
    DOI
    10.1016/S1474-4422(10)70105-8
    PubMed ID
    20610347
    Additional Links
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079431/pdf/nihms264471.pdf
    Abstract
    Over the past 10 years, there has been an increasing use of molecular markers in the assessment and management of adult malignant gliomas. Some molecular signatures are used diagnostically to help pathologists classify tumours, whereas others are used to estimate prognosis for patients. Most crucial, however, are those markers that are used to predict response to certain therapies, thereby directing clinicians to a particular treatment while avoiding other potentially deleterious therapies. Recently, large-scale genome-wide surveys have been used to identify new biomarkers that have been rapidly developed as diagnostic and prognostic tools. Given these developments, the pace of discovery of new molecular assays will quicken to facilitate personalised medicine in the setting of malignant glioma.
    Item Type
    Article
    Language
    en
    ISSN
    1474-4465
    ae974a485f413a2113503eed53cd6c53
    10.1016/S1474-4422(10)70105-8
    Scopus Count
    Collections
    Cork University Hospital

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