Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers.
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Affiliation
Pathology Service, Massachusetts General Hospital, Boston, MA 02114, USA.Issue Date
2010-07MeSH
Brain NeoplasmsGlioma
Humans
Pathology, Molecular
Tumor Markers, Biological
Metadata
Show full item recordCitation
Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers. 2010, 9 (7):717-26 Lancet NeurolPublisher
ElsevierJournal
Lancet neurologyDOI
10.1016/S1474-4422(10)70105-8PubMed ID
20610347Abstract
Over the past 10 years, there has been an increasing use of molecular markers in the assessment and management of adult malignant gliomas. Some molecular signatures are used diagnostically to help pathologists classify tumours, whereas others are used to estimate prognosis for patients. Most crucial, however, are those markers that are used to predict response to certain therapies, thereby directing clinicians to a particular treatment while avoiding other potentially deleterious therapies. Recently, large-scale genome-wide surveys have been used to identify new biomarkers that have been rapidly developed as diagnostic and prognostic tools. Given these developments, the pace of discovery of new molecular assays will quicken to facilitate personalised medicine in the setting of malignant glioma.Item Type
ArticleLanguage
enISSN
1474-4465ae974a485f413a2113503eed53cd6c53
10.1016/S1474-4422(10)70105-8
Scopus Count
Collections
Related articles
- Molecular markers of glioma: an update on recent progress and perspectives.
- Authors: Gupta K, Salunke P
- Issue date: 2012 Dec
- Molecular diagnostics of gliomas: the clinical perspective.
- Authors: Tabatabai G, Stupp R, van den Bent MJ, Hegi ME, Tonn JC, Wick W, Weller M
- Issue date: 2010 Nov
- Molecular diagnostics of gliomas: state of the art.
- Authors: Riemenschneider MJ, Jeuken JW, Wesseling P, Reifenberger G
- Issue date: 2010 Nov
- Progress on molecular biomarkers and classification of malignant gliomas.
- Authors: Zhang C, Bao Z, Zhang W, Jiang T
- Issue date: 2013 Jun
- Updates in Pediatric Glioma Pathology.
- Authors: Hakar MH, Wood MD
- Issue date: 2020 Dec