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    Phase I/II safety study of transfusion of prion-filtered red cell concentrates in transfusion-dependent patients.

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    Authors
    Cahill, M R
    Murphy, T
    Khan, M
    Fagan, J
    Murphy, W G
    Affiliation
    Department of Haematology, Cork University Hospital, Cork, Ireland. maryr.cahill@hse.ie
    Issue Date
    2010-08-01
    MeSH
    Adult
    Creutzfeldt-Jakob Syndrome
    Erythrocyte Transfusion
    Erythrocytes
    Hemofiltration
    Humans
    Prions
    
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    Citation
    Phase I/II safety study of transfusion of prion-filtered red cell concentrates in transfusion-dependent patients. 2010, 99 (2):174-6 Vox Sang.
    Journal
    Vox sanguinis
    URI
    http://hdl.handle.net/10147/200261
    DOI
    10.1111/j.1423-0410.2010.01330.x
    PubMed ID
    20345513
    Abstract
    Variant Creutzfeldt-Jakob (vCJD) is a fatal transfusion transmissible prion infection. No test for vCJD in the donor population is currently available. Therefore, prion removal by filtration of red cell concentrate (RCC) is an attractive option for prevention.
    Twenty patients were recruited with ethical permission, to receive clinically necessary transfusion containing one unit of pfRCC. Follow-up at 24 hours, 6 weeks and 6 months was undertaken. A second pfRCC was administered to 6 patients with similar follow up. pfRCC were prepared using the CE marked P-Capt device by the IBTS.
    In 20 transfused patients undergoing one exposure to a prion filtered unit, no attributable adverse events were noted. A subset of these (n = 6) underwent re-exposure to a further filtered unit without incident.
    This phase 1/11 clinical study provides encouraging data on safety of prion filtration which can be used to plan more extensive studies on the use of filtered blood in adults and children.
    Item Type
    Article
    Language
    en
    ISSN
    1423-0410
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1423-0410.2010.01330.x
    Scopus Count
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    Cork University Hospital

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