Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis: association with toll-like receptor 4 expression and plasma levels of interleukin 8.
AuthorsShanab, Ahmed Abu
Quigley, Eamonn M M
AffiliationAlimentary Pharmabiotic Centre, Department of Medicine, University College Cork, National University of Ireland, Cork, Ireland.
Gene Expression Regulation
Toll-Like Receptor 4
MetadataShow full item record
CitationSmall intestinal bacterial overgrowth in nonalcoholic steatohepatitis: association with toll-like receptor 4 expression and plasma levels of interleukin 8. 2011, 56 (5):1524-34 Dig. Dis. Sci.
JournalDigestive diseases and sciences
AbstractNASH patients have a higher prevalence of small intestinal bacterial overgrowth which is associated with enhanced expression of TLR-4 and release of IL-8. SIBO may have an important role in NASH through interactions with TLR-4 and induction of the pro-inflammatory cytokine, IL-8.