Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis.
AffiliationDepartment of Restorative Dentistry, Cork University Dental School and Hospital, Wilton, Ireland. firstname.lastname@example.org
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CitationOxidative and inflammatory status in Type 2 diabetes patients with periodontitis. 2011, 38 (10):894-901 J. Clin. Periodontol.
JournalJournal of clinical periodontology
AbstractTo determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes.
A comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS.
pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower β-cell function (HOMA-β; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups.
Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.
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