The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery.
Authors
Cooley, Sharon MDonnelly, Jennifer C
Collins, Claire
Geary, Michael P
Rodeck, Charles H
Hindmarsh, Peter C
Affiliation
Rotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.comIssue Date
2010-05Keywords
PREGNANCYGROWTH
MeSH
AdultAlcohol Drinking
Cohort Studies
Female
Gestational Age
Humans
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Pregnancy
Premature Birth
Prospective Studies
Smoking
Metadata
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The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery. 2010, 38 (3):255-9 J Perinat MedJournal
Journal of perinatal medicineDOI
10.1515/JPM.2010.019PubMed ID
20121533Additional Links
http://www.reference-global.com/doi/abs/10.1515/JPM.2010.019?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmedAbstract
To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery.Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery.
There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02).
Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.
Item Type
ArticleLanguage
enISSN
1619-3997ae974a485f413a2113503eed53cd6c53
10.1515/JPM.2010.019
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