Second trimester cervical length and risk of preterm birth in women with twin gestations treated with 17-α hydroxyprogesterone caproate.
dc.contributor.author | Durnwald, Celeste P | |
dc.contributor.author | Momirova, Valerija | |
dc.contributor.author | Rouse, Dwight J | |
dc.contributor.author | Caritis, Steve N | |
dc.contributor.author | Peaceman, Alan M | |
dc.contributor.author | Sciscione, Anthony | |
dc.contributor.author | Varner, Michael W | |
dc.contributor.author | Malone, Fergal D | |
dc.contributor.author | Mercer, Brian M | |
dc.contributor.author | Thorp, John M | |
dc.contributor.author | Sorokin, Yoram | |
dc.contributor.author | Carpenter, Marshall W | |
dc.contributor.author | Lo, Julie | |
dc.contributor.author | Ramin, Susan M | |
dc.contributor.author | Harper, Margaret | |
dc.contributor.author | Spong, Catherine Y | |
dc.date.accessioned | 2011-11-18T15:08:59Z | |
dc.date.available | 2011-11-18T15:08:59Z | |
dc.date.issued | 2010-12 | |
dc.identifier.citation | Second trimester cervical length and risk of preterm birth in women with twin gestations treated with 17-α hydroxyprogesterone caproate. 2010, 23 (12):1360-4 J. Matern. Fetal. Neonatal. Med. | en |
dc.identifier.issn | 1476-4954 | |
dc.identifier.pmid | 20441408 | |
dc.identifier.doi | 10.3109/14767051003702786 | |
dc.identifier.uri | http://hdl.handle.net/10147/189974 | |
dc.description | OBJECTIVE: To compare rates of preterm birth before 35 weeks based on cervical length measurement at 16-20 weeks in women with twin gestations who received 17-α hydroxyprogesterone caproate (17OHPC) or placebo. METHODS: This is a secondary analysis of a randomised, double-blind, placebo-controlled trial of twin gestations exposed to 17OHPC or placebo. Baseline transvaginal ultrasound evaluation of cervical length was performed prior to treatment assignment at 16-20 weeks. Cervical length measurements were categorised according to the 10th, 25th, 50th and 75th percentiles in the women studied. The effect of 17OHPC administration in women with a short (25th percentile) and long (75th percentile) cervix was evaluated. RESULTS: Of 661 twin gestations studied, 221 (33.4%) women enrolled at 11 centers underwent cervical length measurement. The 10th, 25th, 50th, 75th percentiles for cervical length at 16-20 weeks were 32, 36, 40 and 44 mm, respectively. The risk of preterm birth <35 weeks was increased in women with a cervical length <25th percentile (55.8 vs. 36.9%, p=0.02). However, a cervical length >75th percentile at this gestational age interval was not protective for preterm birth (36.5 vs. 42.9%, p=0.42). Administration of 17OHPC did not reduce preterm birth before 35 weeks among those with either a short or a long cervix (64.3 vs. 45.8%, p=0.18 and 38.1 vs. 35.5%, p=0.85, respectively). CONCLUSION: Women with twin gestations and a cervical length below the 25th percentile at 16-20 weeks had higher rates of preterm birth. In this subgroup of women, 17 OHPC did not prevent preterm birth before 35 weeks gestation. A cervical length above the 75th percentile at 16-20 weeks did not significantly reduce the risk of preterm birth in this high risk population. | en |
dc.description.abstract | To compare rates of preterm birth before 35 weeks based on cervical length measurement at 16-20 weeks in women with twin gestations who received 17-α hydroxyprogesterone caproate (17OHPC) or placebo. | |
dc.description.abstract | This is a secondary analysis of a randomised, double-blind, placebo-controlled trial of twin gestations exposed to 17OHPC or placebo. Baseline transvaginal ultrasound evaluation of cervical length was performed prior to treatment assignment at 16-20 weeks. Cervical length measurements were categorised according to the 10th, 25th, 50th and 75th percentiles in the women studied. The effect of 17OHPC administration in women with a short (25th percentile) and long (75th percentile) cervix was evaluated. | |
dc.description.abstract | Of 661 twin gestations studied, 221 (33.4%) women enrolled at 11 centers underwent cervical length measurement. The 10th, 25th, 50th, 75th percentiles for cervical length at 16-20 weeks were 32, 36, 40 and 44 mm, respectively. The risk of preterm birth <35 weeks was increased in women with a cervical length <25th percentile (55.8 vs. 36.9%, p=0.02). However, a cervical length >75th percentile at this gestational age interval was not protective for preterm birth (36.5 vs. 42.9%, p=0.42). Administration of 17OHPC did not reduce preterm birth before 35 weeks among those with either a short or a long cervix (64.3 vs. 45.8%, p=0.18 and 38.1 vs. 35.5%, p=0.85, respectively). | |
dc.description.abstract | Women with twin gestations and a cervical length below the 25th percentile at 16-20 weeks had higher rates of preterm birth. In this subgroup of women, 17 OHPC did not prevent preterm birth before 35 weeks gestation. A cervical length above the 75th percentile at 16-20 weeks did not significantly reduce the risk of preterm birth in this high risk population. | |
dc.language.iso | en | en |
dc.relation.url | http://informahealthcare.com/doi/abs/10.3109/14767051003702786 | en |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999406/pdf/nihms253511.pdf | en |
dc.subject.mesh | Adult | |
dc.subject.mesh | Cervix Uteri | |
dc.subject.mesh | Double-Blind Method | |
dc.subject.mesh | Female | |
dc.subject.mesh | Gestational Age | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Hydroxyprogesterones | |
dc.subject.mesh | Placebos | |
dc.subject.mesh | Pregnancy | |
dc.subject.mesh | Pregnancy Trimester, Second | |
dc.subject.mesh | Premature Birth | |
dc.subject.mesh | Risk Factors | |
dc.subject.mesh | Twins | |
dc.title | Second trimester cervical length and risk of preterm birth in women with twin gestations treated with 17-α hydroxyprogesterone caproate. | en |
dc.type | Article | en |
dc.contributor.department | Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH 43210, USA. celeste.durnwald@osumc.edu | en |
dc.identifier.journal | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians | en |
dc.description.province | Leinster | |
html.description.abstract | To compare rates of preterm birth before 35 weeks based on cervical length measurement at 16-20 weeks in women with twin gestations who received 17-α hydroxyprogesterone caproate (17OHPC) or placebo. | |
html.description.abstract | This is a secondary analysis of a randomised, double-blind, placebo-controlled trial of twin gestations exposed to 17OHPC or placebo. Baseline transvaginal ultrasound evaluation of cervical length was performed prior to treatment assignment at 16-20 weeks. Cervical length measurements were categorised according to the 10th, 25th, 50th and 75th percentiles in the women studied. The effect of 17OHPC administration in women with a short (25th percentile) and long (75th percentile) cervix was evaluated. | |
html.description.abstract | Of 661 twin gestations studied, 221 (33.4%) women enrolled at 11 centers underwent cervical length measurement. The 10th, 25th, 50th, 75th percentiles for cervical length at 16-20 weeks were 32, 36, 40 and 44 mm, respectively. The risk of preterm birth <35 weeks was increased in women with a cervical length <25th percentile (55.8 vs. 36.9%, p=0.02). However, a cervical length >75th percentile at this gestational age interval was not protective for preterm birth (36.5 vs. 42.9%, p=0.42). Administration of 17OHPC did not reduce preterm birth before 35 weeks among those with either a short or a long cervix (64.3 vs. 45.8%, p=0.18 and 38.1 vs. 35.5%, p=0.85, respectively). | |
html.description.abstract | Women with twin gestations and a cervical length below the 25th percentile at 16-20 weeks had higher rates of preterm birth. In this subgroup of women, 17 OHPC did not prevent preterm birth before 35 weeks gestation. A cervical length above the 75th percentile at 16-20 weeks did not significantly reduce the risk of preterm birth in this high risk population. |