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dc.contributor.authorD'Adamo, Ebe
dc.contributor.authorNorthrup, Veronika
dc.contributor.authorWeiss, Ram
dc.contributor.authorSantoro, Nicola
dc.contributor.authorPierpont, Bridget
dc.contributor.authorSavoye, Mary
dc.contributor.authorO'Malley, Grace
dc.contributor.authorCaprio, Sonia
dc.date.accessioned2011-11-01T11:55:09Z
dc.date.available2011-11-01T11:55:09Z
dc.date.issued2010-09
dc.identifier.citationEthnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion. 2010, 92 (3):500-8 Am. J. Clin. Nutr.en
dc.identifier.issn1938-3207
dc.identifier.pmid20573788
dc.identifier.doi10.3945/ajcn.2010.29270
dc.identifier.urihttp://hdl.handle.net/10147/188295
dc.description.abstractRecently, the deleterious metabolic effects of visceral fat [visceral adipose tissue (VAT)] deposition were challenged, and liver fat emerged as having a key independent role in the modulation of cardiometabolic risk factors.
dc.description.abstractWe explored the relation between liver fat content and VAT in 3 ethnic groups and evaluated whether the ethnic differences in the distributions of lipoprotein concentrations and sizes were associated with the hepatic fat fraction (HFF), VAT, or both.
dc.description.abstractIn a multiethnic group of 33 white, 33 African American, and 33 Hispanic obese adolescents with normal glucose tolerance, we measured VAT and HFF by using magnetic resonance imaging. Fasting lipoprotein particle number and size were measured by using nuclear magnetic resonance spectroscopy. To assess the association between VAT and HFF, we categorized VAT into tertiles.
dc.description.abstractIn each ethnic group, HFF values increased between successive tertiles of VAT. After multivariate adjustment and in comparison with the 2 other groups, African Americans showed lower triglyceride (P = 0.001) and higher HDL (P = 0.03) concentrations, lower concentrations of total (P = 0.007), large (P = 0.005), and medium (P lt 0.0001) VLDL, but higher concentrations of large HDL particles (P = 0.01) and larger HDL (P = 0.005). In multivariate linear models, independent of ethnicity, VAT was a significant predictor for large HDL (P = 0.003) and total small LDL (P = 0.001) concentrations, whereas HFF significantly predicted large VLDL (P = 0.03) concentrations.
dc.description.abstractLiver fat accretion, independent of VAT, may play a role in the ethnic differences seen in large VLDL particles. This trial was registered at clinicaltrials.gov as NCT00536250.
dc.description.sponsorshipIrish Fulbright Commissionen
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/20573788en
dc.subject.meshAdolescent
dc.subject.meshAfrican Americans
dc.subject.meshChild
dc.subject.meshEuropean Continental Ancestry Group
dc.subject.meshFemale
dc.subject.meshHispanic Americans
dc.subject.meshHumans
dc.subject.meshIntra-Abdominal Fat
dc.subject.meshLipid Metabolism
dc.subject.meshLipoproteins
dc.subject.meshLiver
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshObesity
dc.subject.meshParticle Size
dc.subject.meshTriglycerides
dc.titleEthnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion.en
dc.typeArticle In Pressen
dc.contributor.departmentDepartment of Pediatrics, Yale University, New Haven, CT, USA.en
dc.identifier.journalThe American journal of clinical nutritionen
dc.description.provinceLeinster
html.description.abstractRecently, the deleterious metabolic effects of visceral fat [visceral adipose tissue (VAT)] deposition were challenged, and liver fat emerged as having a key independent role in the modulation of cardiometabolic risk factors.
html.description.abstractWe explored the relation between liver fat content and VAT in 3 ethnic groups and evaluated whether the ethnic differences in the distributions of lipoprotein concentrations and sizes were associated with the hepatic fat fraction (HFF), VAT, or both.
html.description.abstractIn a multiethnic group of 33 white, 33 African American, and 33 Hispanic obese adolescents with normal glucose tolerance, we measured VAT and HFF by using magnetic resonance imaging. Fasting lipoprotein particle number and size were measured by using nuclear magnetic resonance spectroscopy. To assess the association between VAT and HFF, we categorized VAT into tertiles.
html.description.abstractIn each ethnic group, HFF values increased between successive tertiles of VAT. After multivariate adjustment and in comparison with the 2 other groups, African Americans showed lower triglyceride (P = 0.001) and higher HDL (P = 0.03) concentrations, lower concentrations of total (P = 0.007), large (P = 0.005), and medium (P lt 0.0001) VLDL, but higher concentrations of large HDL particles (P = 0.01) and larger HDL (P = 0.005). In multivariate linear models, independent of ethnicity, VAT was a significant predictor for large HDL (P = 0.003) and total small LDL (P = 0.001) concentrations, whereas HFF significantly predicted large VLDL (P = 0.03) concentrations.
html.description.abstractLiver fat accretion, independent of VAT, may play a role in the ethnic differences seen in large VLDL particles. This trial was registered at clinicaltrials.gov as NCT00536250.


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