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    Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses.

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    Authors
    Hogan, Andrew E
    Corrigan, Michelle A
    O'Reilly, Vincent
    Gaoatswe, Gadintshware
    O'Connell, Jean
    Doherty, Derek G
    Lynch, Lydia
    O'Shea, Donal
    Affiliation
    Obesity Immunology Group, Education and Research Centre, St Vincents University Hospital, UCD, Dublin 4, Ireland. Andrew.Hogan.3@ucd.ie
    Issue Date
    2011-09
    MeSH
    Antigens, CD
    Antigens, CD56
    Antigens, Differentiation, T-Lymphocyte
    Cells, Cultured
    Cytokines
    Cytotoxicity Tests, Immunologic
    Cytotoxicity, Immunologic
    Galactosylceramides
    Hela Cells
    Humans
    Lectins, C-Type
    Lymphocyte Activation
    Lysosomal-Associated Membrane Protein 1
    Natural Killer T-Cells
    Neoplasms
    Smoke
    Smoking
    Tobacco
    Up-Regulation
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    Citation
    Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. 2011, 140 (3):229-35 Clin. Immunol.
    Journal
    Clinical immunology (Orlando, Fla.)
    URI
    http://hdl.handle.net/10147/146561
    DOI
    10.1016/j.clim.2011.01.011
    PubMed ID
    21684213
    Abstract
    Invariant natural killer T (iNKT) cells are a minor subset of human T cells which express the invariant T cell receptor Vα24 Jα18 and recognize glycolipids presented on CD1d. Invariant NKT cells are important immune regulators and can initiate anti-tumor responses through early potent cytokine production. Studies show that iNKT cells are defective in certain cancers. Cigarette smoke contains many carcinogens and is implicated directly and indirectly in many cancers. We investigated the effects of cigarette smoke on the circulating iNKT cell number and function. We found that the iNKT cell frequency is significantly reduced in cigarette smoking subjects. Invariant NKT cells exposed to cigarette smoke extract (CSE) showed significant defects in cytokine production and the ability to kill target cells. CSE inhibits the upregulation of CD107 but not CD69 or CD56 on iNKT cells. These findings suggest that CSE has a specific effect on iNKT cell anti-tumor responses, which may contribute to the role of smoking in the development of cancer.
    Item Type
    Article
    Language
    en
    ISSN
    1521-7035
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clim.2011.01.011
    Scopus Count
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