Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses.
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Authors
Hogan, Andrew ECorrigan, Michelle A
O'Reilly, Vincent
Gaoatswe, Gadintshware
O'Connell, Jean
Doherty, Derek G
Lynch, Lydia
O'Shea, Donal
Affiliation
Obesity Immunology Group, Education and Research Centre, St Vincents University Hospital, UCD, Dublin 4, Ireland. Andrew.Hogan.3@ucd.ieIssue Date
2011-09MeSH
Antigens, CDAntigens, CD56
Antigens, Differentiation, T-Lymphocyte
Cells, Cultured
Cytokines
Cytotoxicity Tests, Immunologic
Cytotoxicity, Immunologic
Galactosylceramides
Hela Cells
Humans
Lectins, C-Type
Lymphocyte Activation
Lysosomal-Associated Membrane Protein 1
Natural Killer T-Cells
Neoplasms
Smoke
Smoking
Tobacco
Up-Regulation
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Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. 2011, 140 (3):229-35 Clin. Immunol.Journal
Clinical immunology (Orlando, Fla.)DOI
10.1016/j.clim.2011.01.011PubMed ID
21684213Abstract
Invariant natural killer T (iNKT) cells are a minor subset of human T cells which express the invariant T cell receptor Vα24 Jα18 and recognize glycolipids presented on CD1d. Invariant NKT cells are important immune regulators and can initiate anti-tumor responses through early potent cytokine production. Studies show that iNKT cells are defective in certain cancers. Cigarette smoke contains many carcinogens and is implicated directly and indirectly in many cancers. We investigated the effects of cigarette smoke on the circulating iNKT cell number and function. We found that the iNKT cell frequency is significantly reduced in cigarette smoking subjects. Invariant NKT cells exposed to cigarette smoke extract (CSE) showed significant defects in cytokine production and the ability to kill target cells. CSE inhibits the upregulation of CD107 but not CD69 or CD56 on iNKT cells. These findings suggest that CSE has a specific effect on iNKT cell anti-tumor responses, which may contribute to the role of smoking in the development of cancer.Item Type
ArticleLanguage
enISSN
1521-7035ae974a485f413a2113503eed53cd6c53
10.1016/j.clim.2011.01.011
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