Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses.
AuthorsHogan, Andrew E
Corrigan, Michelle A
Doherty, Derek G
AffiliationObesity Immunology Group, Education and Research Centre, St Vincents University Hospital, UCD, Dublin 4, Ireland. Andrew.Hogan.email@example.com
Antigens, Differentiation, T-Lymphocyte
Cytotoxicity Tests, Immunologic
Lysosomal-Associated Membrane Protein 1
Natural Killer T-Cells
MetadataShow full item record
CitationCigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. 2011, 140 (3):229-35 Clin. Immunol.
JournalClinical immunology (Orlando, Fla.)
AbstractInvariant natural killer T (iNKT) cells are a minor subset of human T cells which express the invariant T cell receptor Vα24 Jα18 and recognize glycolipids presented on CD1d. Invariant NKT cells are important immune regulators and can initiate anti-tumor responses through early potent cytokine production. Studies show that iNKT cells are defective in certain cancers. Cigarette smoke contains many carcinogens and is implicated directly and indirectly in many cancers. We investigated the effects of cigarette smoke on the circulating iNKT cell number and function. We found that the iNKT cell frequency is significantly reduced in cigarette smoking subjects. Invariant NKT cells exposed to cigarette smoke extract (CSE) showed significant defects in cytokine production and the ability to kill target cells. CSE inhibits the upregulation of CD107 but not CD69 or CD56 on iNKT cells. These findings suggest that CSE has a specific effect on iNKT cell anti-tumor responses, which may contribute to the role of smoking in the development of cancer.
- Exposure to cigarette smoke suppresses IL-15 generation and its regulatory NK cell functions in poly I:C-augmented human PBMCs.
- Authors: Mian MF, Pek EA, Mossman KL, Stämpfli MR, Ashkar AA
- Issue date: 2009 Sep
- Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities.
- Authors: Wu L, Gabriel CL, Parekh VV, Van Kaer L
- Issue date: 2009 Jun
- Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide.
- Authors: Hogan AE, O'Reilly V, Dunne MR, Dere RT, Zeng SG, O'Brien C, Amu S, Fallon PG, Exley MA, O'Farrelly C, Zhu X, Doherty DG
- Issue date: 2011 Aug
- Invariant and noninvariant natural killer T cells exert opposite regulatory functions on the immune response during murine schistosomiasis.
- Authors: Mallevaey T, Fontaine J, Breuilh L, Paget C, Castro-Keller A, Vendeville C, Capron M, Leite-de-Moraes M, Trottein F, Faveeuw C
- Issue date: 2007 May
- Cytokine-dependent modification of IL-12p70 and IL-23 balance in dendritic cells by ligand activation of Valpha24 invariant NKT cells.
- Authors: Uemura Y, Liu TY, Narita Y, Suzuki M, Nakatsuka R, Araki T, Matsumoto M, Iwai LK, Hirosawa N, Matsuoka Y, Murakami M, Kimura T, Hase M, Kohno H, Sasaki Y, Ichihara Y, Ishihara O, Kikuchi H, Sakamoto Y, Jiao SC, Senju S, Sonoda Y
- Issue date: 2009 Jul 1