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dc.contributor.authorMinnock, Patricia
dc.contributor.authorKirwan, John
dc.contributor.authorBresnihan, Barry
dc.date.accessioned2011-10-21T13:44:17Z
dc.date.available2011-10-21T13:44:17Z
dc.date.issued2009-12
dc.identifier.citationFatigue is a reliable, sensitive and unique outcome measure in rheumatoid arthritis. 2009, 48 (12):1533-6 Rheumatology (Oxford)en
dc.identifier.issn1462-0332
dc.identifier.pmid19773406
dc.identifier.doi10.1093/rheumatology/kep287
dc.identifier.urihttp://hdl.handle.net/10147/146354
dc.description.abstractFatigue is an important symptom in patients with RA. Measurement of fatigue in clinical trials and in clinical practice requires scales that are reproducible, sensitive to change and practical. This study examined the reliability and sensitivity to change of fatigue and its relative independence as an outcome measure in RA.
dc.description.abstractSuccessive patients referred to the rheumatology clinic at St Vincent's University Hospital and Our Lady's Hospice were evaluated. Clinical assessments were undertaken at baseline and 3 months after commencing TNF-alpha blockade. Fatigue was measured using an 11-point numeric rating scale (NRS). Sensitivity to change when compared with current core set outcome measures was determined by calculation of the standardized response mean (SRM). Multiple regression analysis was employed to determine the independent variance of fatigue scores relative to the core set.
dc.description.abstractForty-nine patients were evaluated. At baseline, mean (s.d.) fatigue scores were 6.7 +/- 2.1. At 3 months, fatigue scores had fallen to 4.3 +/- 2.6 (P < 0.001). Test-retest intraclass correlation coefficient for the NRS was 0.79 (P < 0.008). Fatigue was ranked third for relative sensitivity to change as shown by SRM: pain, 1.37; tender joint count (TJC), 1.09; fatigue, 0.92; swollen joint count (SJC), 0.86; HAQ, 0.82; CRP, 0.69; and patient global health (GH), 0.25. The relative independent variance in fatigue of 22% was higher than that of the core set: TJC, 20%; pain, 19%; SJC, 16%; GH, 8%; HAQ, 7%; and CRP, 8%.
dc.description.abstractThis study demonstrates that measures of fatigue are reliable and sensitive to change, and should be considered for inclusion as a core outcome measure in RA.
dc.language.isoenen
dc.relation.urldoi: 10.1093/rheumatology/kep287en
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntirheumatic Agents
dc.subject.meshArthritis, Rheumatoid
dc.subject.meshEpidemiologic Methods
dc.subject.meshFatigue
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPain Measurement
dc.subject.meshTreatment Outcome
dc.subject.meshTumor Necrosis Factor-alpha
dc.subject.meshYoung Adult
dc.titleFatigue is a reliable, sensitive and unique outcome measure in rheumatoid arthritis.en
dc.typeArticleen
dc.contributor.departmentRheumatology Rehabilitation, Our Lady's Hospice, Harold's Cross, Dublin 6, Ireland. pminnock@olh.ieen
dc.identifier.journalRheumatology (Oxford, England)en
html.description.abstractFatigue is an important symptom in patients with RA. Measurement of fatigue in clinical trials and in clinical practice requires scales that are reproducible, sensitive to change and practical. This study examined the reliability and sensitivity to change of fatigue and its relative independence as an outcome measure in RA.
html.description.abstractSuccessive patients referred to the rheumatology clinic at St Vincent's University Hospital and Our Lady's Hospice were evaluated. Clinical assessments were undertaken at baseline and 3 months after commencing TNF-alpha blockade. Fatigue was measured using an 11-point numeric rating scale (NRS). Sensitivity to change when compared with current core set outcome measures was determined by calculation of the standardized response mean (SRM). Multiple regression analysis was employed to determine the independent variance of fatigue scores relative to the core set.
html.description.abstractForty-nine patients were evaluated. At baseline, mean (s.d.) fatigue scores were 6.7 +/- 2.1. At 3 months, fatigue scores had fallen to 4.3 +/- 2.6 (P < 0.001). Test-retest intraclass correlation coefficient for the NRS was 0.79 (P < 0.008). Fatigue was ranked third for relative sensitivity to change as shown by SRM: pain, 1.37; tender joint count (TJC), 1.09; fatigue, 0.92; swollen joint count (SJC), 0.86; HAQ, 0.82; CRP, 0.69; and patient global health (GH), 0.25. The relative independent variance in fatigue of 22% was higher than that of the core set: TJC, 20%; pain, 19%; SJC, 16%; GH, 8%; HAQ, 7%; and CRP, 8%.
html.description.abstractThis study demonstrates that measures of fatigue are reliable and sensitive to change, and should be considered for inclusion as a core outcome measure in RA.


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