Show simple item record

dc.contributor.authorVarghese, M
dc.contributor.authorCafferkey, M
dc.contributor.authorO'Regan, M
dc.contributor.authorMonavari, A A
dc.contributor.authorTreacy, E P
dc.date.accessioned2011-10-07T14:05:10Z
dc.date.available2011-10-07T14:05:10Z
dc.date.issued2011-01
dc.identifier.citationShould children with inherited metabolic disorders receive varicella vaccination? 2011, 96 (1):99-100 Arch. Dis. Child.en
dc.identifier.issn1468-2044
dc.identifier.pmid19846994
dc.identifier.doi10.1136/adc.2008.147934
dc.identifier.urihttp://hdl.handle.net/10147/144297
dc.descriptionThe aim was to determine the rate of varicella infection and complications in children with disorders of intermediary metabolism (IEM) between the ages of 1 and 16 years attending our national metabolic referral centre. Of 126 children identified, a response was received from 122. A history of previous varicella infection was identified in 64 cases (53%) and of varicella vaccination in 5 (4%). Fifty-three (43%) patients apparently did not have a history of clinical varicella infection. Of the 64 children with a history of varicella infection, five required hospitalisation for complications, including life-threatening lactic acidosis in one patient with mitochondrial disease and metabolic decompensation in four patients. In conclusion, varicella infection may cause an increased risk of metabolic decompensation in patients with IEMs. We propose that a trial of varicella vaccination be considered for this cohort of patients with monitoring of its safety and efficacy.en
dc.description.abstractThe aim was to determine the rate of varicella infection and complications in children with disorders of intermediary metabolism (IEM) between the ages of 1 and 16 years attending our national metabolic referral centre. Of 126 children identified, a response was received from 122. A history of previous varicella infection was identified in 64 cases (53%) and of varicella vaccination in 5 (4%). Fifty-three (43%) patients apparently did not have a history of clinical varicella infection. Of the 64 children with a history of varicella infection, five required hospitalisation for complications, including life-threatening lactic acidosis in one patient with mitochondrial disease and metabolic decompensation in four patients. In conclusion, varicella infection may cause an increased risk of metabolic decompensation in patients with IEMs. We propose that a trial of varicella vaccination be considered for this cohort of patients with monitoring of its safety and efficacy.
dc.language.isoenen
dc.relation.urlhttp://adc.bmj.com/content/96/1/99.longen
dc.subject.meshAdolescent
dc.subject.meshChickenpox
dc.subject.meshChickenpox Vaccine
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshHospitalization
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshIreland
dc.subject.meshMetabolism, Inborn Errors
dc.subject.meshVaccination
dc.titleShould children with inherited metabolic disorders receive varicella vaccination?en
dc.typeArticleen
dc.contributor.departmentNational Centre for Inherited Metabolic Disorders, Children's University Hospital, Dublin, Ireland.en
dc.identifier.journalArchives of disease in childhooden
dc.description.provinceLeinster
html.description.abstractThe aim was to determine the rate of varicella infection and complications in children with disorders of intermediary metabolism (IEM) between the ages of 1 and 16 years attending our national metabolic referral centre. Of 126 children identified, a response was received from 122. A history of previous varicella infection was identified in 64 cases (53%) and of varicella vaccination in 5 (4%). Fifty-three (43%) patients apparently did not have a history of clinical varicella infection. Of the 64 children with a history of varicella infection, five required hospitalisation for complications, including life-threatening lactic acidosis in one patient with mitochondrial disease and metabolic decompensation in four patients. In conclusion, varicella infection may cause an increased risk of metabolic decompensation in patients with IEMs. We propose that a trial of varicella vaccination be considered for this cohort of patients with monitoring of its safety and efficacy.


This item appears in the following Collection(s)

Show simple item record