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    Should children with inherited metabolic disorders receive varicella vaccination?

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    Authors
    Varghese, M
    Cafferkey, M
    O'Regan, M
    Monavari, A A
    Treacy, E P
    Affiliation
    National Centre for Inherited Metabolic Disorders, Children's University Hospital, Dublin, Ireland.
    Issue Date
    2011-01
    MeSH
    Adolescent
    Chickenpox
    Chickenpox Vaccine
    Child
    Child, Preschool
    Hospitalization
    Humans
    Infant
    Ireland
    Metabolism, Inborn Errors
    Vaccination
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    Citation
    Should children with inherited metabolic disorders receive varicella vaccination? 2011, 96 (1):99-100 Arch. Dis. Child.
    Journal
    Archives of disease in childhood
    URI
    http://hdl.handle.net/10147/144297
    DOI
    10.1136/adc.2008.147934
    PubMed ID
    19846994
    Additional Links
    http://adc.bmj.com/content/96/1/99.long
    Abstract
    The aim was to determine the rate of varicella infection and complications in children with disorders of intermediary metabolism (IEM) between the ages of 1 and 16 years attending our national metabolic referral centre. Of 126 children identified, a response was received from 122. A history of previous varicella infection was identified in 64 cases (53%) and of varicella vaccination in 5 (4%). Fifty-three (43%) patients apparently did not have a history of clinical varicella infection. Of the 64 children with a history of varicella infection, five required hospitalisation for complications, including life-threatening lactic acidosis in one patient with mitochondrial disease and metabolic decompensation in four patients. In conclusion, varicella infection may cause an increased risk of metabolic decompensation in patients with IEMs. We propose that a trial of varicella vaccination be considered for this cohort of patients with monitoring of its safety and efficacy.
    Item Type
    Article
    Language
    en
    ISSN
    1468-2044
    ae974a485f413a2113503eed53cd6c53
    10.1136/adc.2008.147934
    Scopus Count
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    Children's Health Ireland (CHI) at Temple St (formerly Children's University Hospital, Temple St)

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