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Cortical curvature analysis in MRI-negative temporal lobe epilepsy: A surrogate marker for malformations of cortical development

dc.contributor.authorRonan, Lisa
dc.contributor.authorScanlon, Cathy
dc.contributor.authorMurphy, Kevin
dc.contributor.authorMaguire, Sinead
dc.contributor.authorDelanty, Norman
dc.contributor.authorDoherty, Colin P.
dc.contributor.authorFitzsimons, Mary
dc.date.accessioned2011-08-10T15:33:31Z
dc.date.available2011-08-10T15:33:31Z
dc.date.issued2011-01
dc.identifier.citationCortical curvature analysis in MRI-negative temporal lobe epilepsy: A surrogate marker for malformations of cortical development 2011, 52 (1):28 Epilepsiaen
dc.identifier.issn00139580
dc.identifier.doi10.1111/j.1528-1167.2010.02895.x
dc.identifier.urihttp://hdl.handle.net/10147/139351
dc.descriptionPurpose: To investigate cerebral cortical surface morphology in a magnetic resonance (MRI)–negative temporal lobe epilepsy (TLE) cohort, and to differentiate between the effects on cortical morphology of cerebral volume loss associated with TLE, and abnormalities suggestive of malformations of cortical development (MCDs). Methods: MRI data was gathered for 29 MRI-negative patients and 40 neurologically normal controls. Automated methods of surface reconstruction were applied to all MRI data for the purposes of localized analysis of cortical curvature. As an adjunct to this analysis, measures of whole-brain gray and white matter volumes, as well as cortical thickness, were also generated to determine the degree of whole-brain volume loss in TLE, and its impact on cortical morphology. Results: Automated analysis of the average cortical surface of the patient group revealed an area of abnormal cortical curvature in the basal left temporal lobe. The presence of whole-brain volume loss in TLE was confirmed and found not to contribute to the cortical curvature abnormality in the temporal lobe. These results support the hypothesis that cortical curvature abnormalities in TLE may be indicative of a subtle MCD. Discussion: Subtle MCDs such as abnormal indices of curvature may be associated with partial epilepsy. Analysis of these parameters may increase the diagnostic yield from MRI.en
dc.language.isoenen
dc.relation.urlhttp://doi.wiley.com/10.1111/j.1528-1167.2010.02895.xen
dc.titleCortical curvature analysis in MRI-negative temporal lobe epilepsy: A surrogate marker for malformations of cortical developmenten
dc.typeArticleen
dc.identifier.journalEpilepsiaen
dc.description.provinceConnacht


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