Radiotherapy and breast reconstruction: a meta-analysis.
dc.contributor.author | Barry, M | |
dc.contributor.author | Kell, M R | |
dc.date.accessioned | 2011-08-10T15:42:07Z | |
dc.date.available | 2011-08-10T15:42:07Z | |
dc.date.issued | 2011-05 | |
dc.identifier.citation | Radiotherapy and breast reconstruction: a meta-analysis. 2011, 127 (1):15-22 Breast Cancer Res. Treat. | en |
dc.identifier.issn | 1573-7217 | |
dc.identifier.pmid | 21336948 | |
dc.identifier.doi | 10.1007/s10549-011-1401-x | |
dc.identifier.uri | http://hdl.handle.net/10147/139343 | |
dc.description.abstract | The optimum sequencing of breast reconstruction (BR) in patients receiving postmastectomy radiation therapy (PMRT) is controversial. A comprehensive search of published studies that examined postoperative morbidity following immediate or delayed BR with combined radiotherapy was performed. Medical (MEDLINE & EMBASE) databases were searched and cross-referenced for appropriate studies where morbidity following BR was the primary outcome measured. A total of 1,105 patients were identified from 11 appropriately selected studies. Patients undergoing PMRT and BR are more likely to suffer morbidity compared with patients not receiving PMRT (OR = 4.2; 95% CI, 2.4-7.2 [no PMRT vs. PMRT]). Reconstruction technique was also examined with outcome when PMRT was delivered after BR, and this demonstrated that autologous reconstruction is associated with less morbidity in this setting (OR = 0.21; 95% CI, 0.1-0.4 [autologous vs. implant-based]). Delaying BR until after PMRT had no significant effect on outcome (OR = 0.87; 95% CI, 0.47-1.62 [delayed vs. immediate]). PMRT has a detrimental effect on BR outcome. These results suggest that where immediate reconstruction is undertaken with the necessity of PMRT, an autologous flap results in less morbidity when compared with implant-based reconstruction. | |
dc.language.iso | en | en |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/21336948 | en |
dc.subject.mesh | Breast Neoplasms | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Mammaplasty | |
dc.subject.mesh | Postoperative Period | |
dc.subject.mesh | Treatment Outcome | |
dc.title | Radiotherapy and breast reconstruction: a meta-analysis. | en |
dc.type | Article | en |
dc.contributor.department | Department of Breast Surgery, BreastCheck, Mater Misericordiae University Hospital, Dublin, Ireland. | en |
dc.identifier.journal | Breast cancer research and treatment | en |
dc.description.province | Leinster | |
html.description.abstract | The optimum sequencing of breast reconstruction (BR) in patients receiving postmastectomy radiation therapy (PMRT) is controversial. A comprehensive search of published studies that examined postoperative morbidity following immediate or delayed BR with combined radiotherapy was performed. Medical (MEDLINE & EMBASE) databases were searched and cross-referenced for appropriate studies where morbidity following BR was the primary outcome measured. A total of 1,105 patients were identified from 11 appropriately selected studies. Patients undergoing PMRT and BR are more likely to suffer morbidity compared with patients not receiving PMRT (OR = 4.2; 95% CI, 2.4-7.2 [no PMRT vs. PMRT]). Reconstruction technique was also examined with outcome when PMRT was delivered after BR, and this demonstrated that autologous reconstruction is associated with less morbidity in this setting (OR = 0.21; 95% CI, 0.1-0.4 [autologous vs. implant-based]). Delaying BR until after PMRT had no significant effect on outcome (OR = 0.87; 95% CI, 0.47-1.62 [delayed vs. immediate]). PMRT has a detrimental effect on BR outcome. These results suggest that where immediate reconstruction is undertaken with the necessity of PMRT, an autologous flap results in less morbidity when compared with implant-based reconstruction. |