Show simple item record

dc.contributor.authorKelly, Kevin
dc.contributor.authorMurphy, Philip
dc.date.accessioned2011-07-25T08:37:07Z
dc.date.available2011-07-25T08:37:07Z
dc.date.issued2008-12
dc.identifier.citationAplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q. 2008, 32 (12):1936-8 Leuk. Res.en
dc.identifier.issn0145-2126
dc.identifier.pmid18490054
dc.identifier.doi10.1016/j.leukres.2008.03.012
dc.identifier.urihttp://hdl.handle.net/10147/136796
dc.description.abstractAplastic anaemia (AA) can precede acute lymphoblastic leukaemia (ALL) in 2% of children but this is rarely reported to occur in adults. A 21-year-old male presented with bone marrow failure and bone marrow biopsy showed a profoundly hypocellular marrow. He recovered spontaneously but represented 2 months later when he was diagnosed with pre-B acute lymphoblastic leukaemia. Chromosomal examination revealed 46,XY,del(9)(q13q34). To the best of our knowledge this is the first case to be reported of aplasia preceding ALL with 9q minus as the sole chromosomal abnormality.
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/18490054en
dc.subject.meshAnemia, Aplastic
dc.subject.meshBlast Crisis
dc.subject.meshBone Marrow
dc.subject.meshChromosome Deletion
dc.subject.meshChromosomes, Human, Pair 9
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma
dc.subject.meshYoung Adult
dc.titleAplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q.en
dc.typeArticleen
dc.contributor.departmentDepartment of Haematology, Beaumont Hospital, Dublin, Ireland. kevrkelly77@hotmail.comen
dc.identifier.journalLeukemia researchen
dc.description.provinceLeinster
html.description.abstractAplastic anaemia (AA) can precede acute lymphoblastic leukaemia (ALL) in 2% of children but this is rarely reported to occur in adults. A 21-year-old male presented with bone marrow failure and bone marrow biopsy showed a profoundly hypocellular marrow. He recovered spontaneously but represented 2 months later when he was diagnosed with pre-B acute lymphoblastic leukaemia. Chromosomal examination revealed 46,XY,del(9)(q13q34). To the best of our knowledge this is the first case to be reported of aplasia preceding ALL with 9q minus as the sole chromosomal abnormality.


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record