Aplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q.
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Affiliation
Department of Haematology, Beaumont Hospital, Dublin, Ireland. kevrkelly77@hotmail.comIssue Date
2008-12MeSH
Anemia, AplasticBlast Crisis
Bone Marrow
Chromosome Deletion
Chromosomes, Human, Pair 9
Humans
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Young Adult
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Aplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q. 2008, 32 (12):1936-8 Leuk. Res.Journal
Leukemia researchDOI
10.1016/j.leukres.2008.03.012PubMed ID
18490054Additional Links
http://www.ncbi.nlm.nih.gov/pubmed/18490054Abstract
Aplastic anaemia (AA) can precede acute lymphoblastic leukaemia (ALL) in 2% of children but this is rarely reported to occur in adults. A 21-year-old male presented with bone marrow failure and bone marrow biopsy showed a profoundly hypocellular marrow. He recovered spontaneously but represented 2 months later when he was diagnosed with pre-B acute lymphoblastic leukaemia. Chromosomal examination revealed 46,XY,del(9)(q13q34). To the best of our knowledge this is the first case to be reported of aplasia preceding ALL with 9q minus as the sole chromosomal abnormality.Item Type
ArticleLanguage
enISSN
0145-2126ae974a485f413a2113503eed53cd6c53
10.1016/j.leukres.2008.03.012
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