Direct binding and activation of protein kinase C isoforms by steroid hormones.
AffiliationDepartment of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Smurfit Building, Beaumont Hospital PO Box 9063, Dublin 9, Ireland. AlzamoraR@dom.pitt.edu
Protein Kinase C
MetadataShow full item record
CitationDirect binding and activation of protein kinase C isoforms by steroid hormones. 2008, 73 (9-10):885-8 Steroids
AbstractThe non-genomic action of steroid hormones regulates a wide variety of cellular responses including regulation of ion transport, cell proliferation, migration, death and differentiation. In order to achieve such plethora of effects steroid hormones utilize nearly all known signal transduction pathways. One of the key signalling molecules regulating the non-genomic action of steroid hormones is protein kinase C (PKC). It is thought that rapid action of steroids hormones results from the activation of plasma membrane receptors; however, their molecular identity remains elusive. In recent years, an increasing number of studies have pointed at the selective binding and activation of specific PKC isoforms by steroid hormones. This has led to the hypothesis that PKC could act as a receptor as well as a transducer of the non-genomic effects of these hormones. In this review we summarize the current knowledge of the direct binding and activation of PKC by steroid hormones.
- Direct binding and activation of protein kinase C isoforms by aldosterone and 17beta-estradiol.
- Authors: Alzamora R, Brown LR, Harvey BJ
- Issue date: 2007 Nov
- Membrane-initiated steroid action in breast and prostate cancer.
- Authors: Kampa M, Pelekanou V, Castanas E
- Issue date: 2008 Oct
- Steroid signal transduction activated at the cell membrane: from plants to animals.
- Authors: Marcinkowska E, Wiedłocha A
- Issue date: 2002
- Rapid actions of steroid receptors in cellular signaling pathways.
- Authors: Cato AC, Nestl A, Mink S
- Issue date: 2002 Jun 25
- Receptor mechanisms mediating non-genomic actions of sex steroids.
- Authors: Boonyaratanakornkit V, Edwards DP
- Issue date: 2007 May