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dc.contributor.authorGreene, Catherine M
dc.contributor.authorBranagan, Peter
dc.contributor.authorMcElvaney, Noel G
dc.date.accessioned2011-07-25T08:32:38Z
dc.date.available2011-07-25T08:32:38Z
dc.date.issued2008-12
dc.identifier.citationToll-like receptors as therapeutic targets in cystic fibrosis. 2008, 12 (12):1481-95 Expert Opin. Ther. Targetsen
dc.identifier.issn1744-7631
dc.identifier.pmid19007318
dc.identifier.doi10.1517/14728220802515293
dc.identifier.urihttp://hdl.handle.net/10147/136766
dc.description.abstractBackground: Toll-like receptors (TLRs) are pattern recognition receptors that act as a first-line of defence in the innate immune response by recognising and responding to conserved molecular patterns in microbial factors and endogenous danger signals. Cystic fibrosis (CF)-affected airways represent a milieu potentially rich in TLR agonists and the chronic inflammatory phenotype evident in CF airway epithelial cells is probably due in large part to activation of TLRs. Objective/methods: To examine the prospects of developing novel therapies for CF by targeting TLRs. We outline the expression and function of TLRs and explore the therapeutic potential of naturally-occurring and synthetic TLR inhibitors for CF. Results/conclusion: Modulation of TLRs has therapeutic potential for the inflammatory lung manifestations of CF.
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/19007318en
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal
dc.subject.meshCystic Fibrosis
dc.subject.meshDrug Design
dc.subject.meshGene Expression Regulation
dc.subject.meshHumans
dc.subject.meshToll-Like Receptors
dc.titleToll-like receptors as therapeutic targets in cystic fibrosis.en
dc.typeArticleen
dc.contributor.departmentBeaumont Hospital, Education and Research Centre, Respiratory Research Division, Royal College of Surgeons in Ireland, 9 Dublin, Ireland. cmgreene@rcsi.ieen
dc.identifier.journalExpert opinion on therapeutic targetsen
dc.description.provinceLeinster
html.description.abstractBackground: Toll-like receptors (TLRs) are pattern recognition receptors that act as a first-line of defence in the innate immune response by recognising and responding to conserved molecular patterns in microbial factors and endogenous danger signals. Cystic fibrosis (CF)-affected airways represent a milieu potentially rich in TLR agonists and the chronic inflammatory phenotype evident in CF airway epithelial cells is probably due in large part to activation of TLRs. Objective/methods: To examine the prospects of developing novel therapies for CF by targeting TLRs. We outline the expression and function of TLRs and explore the therapeutic potential of naturally-occurring and synthetic TLR inhibitors for CF. Results/conclusion: Modulation of TLRs has therapeutic potential for the inflammatory lung manifestations of CF.


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