HER-2 positive and p53 negative breast cancers are associated with poor prognosis.
Affiliation
Department of Surgery, Beaumont Hospital, Dublin, Ireland. dalazawi@rcsi.ieIssue Date
2011-06
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HER-2 positive and p53 negative breast cancers are associated with poor prognosis. 2011, 29 (5):365-9 Cancer Invest.Journal
Cancer investigationDOI
10.3109/07357907.2011.584586PubMed ID
21599513Additional Links
http://www.ncbi.nlm.nih.gov/pubmed/21599513Abstract
p53 and HER-2 coexpression in breast cancer has been controversial. These markers were tested using immunohistochemistry and HercepTest. HER-2 expression is related to reduced breast cancer survival (p = .02) . p53 expression relates to HER-2 expression (p = .029). Coexpression between p53 and HER-2 has no relation to prognosis. On univariate and multivariate analysis, combination of HER-2 positive and p53 negative expression was associated with a poor prognosis (p = .018 and p = .027, respectively), while the combination of HER-2 negative and p53 positive expression was associated with a favorable prognosis (p = .022 and p = .010, respectively). Therefore the expression of these markers should be considered collectively.Item Type
ArticleLanguage
enISSN
1532-4192ae974a485f413a2113503eed53cd6c53
10.3109/07357907.2011.584586
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