Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import.

Thumbnail
Name:
21401918.pdf
Size:
2.644Mb
Format:
PDF
Download
Authors
Gu, Lili
Tsuji, Takahiro
Jarboui, Mohamed Ali
Yeo, Geok P
Sheehy, Noreen
Hall, William W
Gautier, Virginie W
Affiliation
UCD-Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin (UCD), Belfield, Dublin 4, Ireland.
Issue Date
2011
MeSH
Active Transport, Cell Nucleus
Animals
COS Cells
Cell Line
Cell Nucleus
Cercopithecus aethiops
Gene Expression Regulation, Viral
HIV-1
Hela Cells
Humans
Jurkat Cells
Karyopherins
Myogenic Regulatory Factors
Nuclear Localization Signals
Protein Binding
U937 Cells
beta Karyopherins
rev Gene Products, Human Immunodeficiency Virus

Metadata
Show full item record
Citation
Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import. 2011, 8:17 Retrovirology
Journal
Retrovirology
URI
http://hdl.handle.net/10147/135955
DOI
10.1186/1742-4690-8-17
PubMed ID
21401918
Additional Links
http://www.ncbi.nlm.nih.gov/pubmed/21401918
Abstract
Rev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy.
Item Type
Article
Language
en
ISSN
1742-4690
Collections