Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import.
Jarboui, Mohamed Ali
Yeo, Geok P
Hall, William W
Gautier, Virginie W
AffiliationUCD-Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin (UCD), Belfield, Dublin 4, Ireland.
MeSHActive Transport, Cell Nucleus
Gene Expression Regulation, Viral
Myogenic Regulatory Factors
Nuclear Localization Signals
rev Gene Products, Human Immunodeficiency Virus
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CitationIntermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import. 2011, 8:17 Retrovirology
AbstractRev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy.